Synergistic regulation of intermolecular interactions to control chiral structures for chiral recognition
Synergistic regulation of intermolecular interactions to control chiral structures for chiral recognition
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DOI：
10.1016/j.cclet.2022.07.056
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发表时间：
2022-08
影响因子：
9.1
通讯作者：
Weilin Chen;Lulu Fu;Zhiqiang Zhu;Jingyan Liu;Linxiu Cheng;Zhou Xu;Hao Dong;Jing Ma;Yibao L
中科院分区：
文献类型：
--
作者：
Weilin Chen;Lulu Fu;Zhiqiang Zhu;Jingyan Liu;Linxiu Cheng;Zhou Xu;Hao Dong;Jing Ma;Yibao L
了解自组装过程的调节机制是调节纳米结构及其特性的必要条件。在此，我们研究了C3对称1,3,5-苯三甲酸甲酯对映体（TPE）在甲醇和水的混合溶剂体系中的自组装机理。所得手性结构用于手性识别。通过多种技术证实了多种非共价相互作用力的协同效应形成手性结构。分子动力学模拟用于表征溶液中 TPE 结构和性能的时间演化。理论结果与实验结果一致。此外，由 TPE 分子构件组装而成的手性结构对二胺化合物具有高度立体选择性。
Understanding the regulatory mechanism of self-assembly processes is a necessity to modulate nanostructures and their properties. Herein, we have studied the mechanism of self-assembly in the C3 symmetric 1,3,5-benzentricarboxylic amino acid methyl ester enantiomers (TPE) in a mixed solvent system consisting of methanol and water. The resultant chiral structure was used for chiral recognition. The formation of chiral structures from the synergistic effect of multiple noncovalent interaction forces was confirmed by various techniques. Molecular dynamics simulations were used to characterize the time evolution of TPE structure and properties in solution. The theoretical results were consistent with the experimental results. Furthermore, the chiral structure assembled by the building blocks of TPE molecules was highly stereoselective for diamine compounds.