Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men
Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men
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DOI：
10.1210/jc.2009-0980
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发表时间：
2009-10-01
影响因子：
5.8
通讯作者：
Andersen, M.
中科院分区：
文献类型：
--
作者：
Frederiksen, L.;Nielsen, T. L.;Andersen, M.
简介：关于脂联素、身体成分和胰岛素抵抗（IR）之间关系的研究一直存在矛盾。目的：我们的目的是在一项以相对健康的年轻男性为研究对象的人群研究中，通过稳态模型评估（HOMA）评估身体成分对脂联素和IR的影响，最大限度地减少年龄、肥胖和严重合并症的可能影响。设计、方法和受试者：一项基于人群的横断面研究，随机抽取了783名20-29岁的男性，来自丹麦中央个人登记处。脂联素使用内部测定法进行评估，IR使用HOMA测定。采用双能X线吸收法测量中心脂肪量（CFM）和下肢脂肪量（LEFM），采用磁共振成像测量内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和大腿脂肪面积（TFA）（r = -0.27; P < 0.001）和SAT（r = -0.20; P < 0.001），与LEFM（r = 0.19; P < 0.001）和TFA（r = 0.18; P < 0.001）呈正相关，而VAT无显著相关性。在多元线性回归分析中，HOMA-IR（因变量）与CFM（r = 0.27; P < 0.001）和SAT（r = 0.15; P < 0.001）显著相关，而LEFM、VAT和TFA不相关。结论：SAT而不是VAT与脂联素水平呈负相关，有趣的是，下肢脂肪与脂联素呈正相关。关注胰岛素抵抗，SAT而不是VAT和TFA独立预测较高的HOMA-IR。脂联素与较低的HOMA-IR独立相关的观察结果必须在其他人群中重复。（临床内分泌代谢杂志94：4010-4015，2009）
Introduction: Studies on the association between adiponectin, body composition, and insulin resistance (IR) have been conflicting.Aim: Our aim was to evaluate the impact of body composition on adiponectin and IR determined by homeostasis model assessment (HOMA) in a population-based study on relatively healthy young men, minimizing the possible effects of age, obesity, and severe comorbidity.Design, Methods, and Subjects: A population-based, cross-sectional study of 783 men aged 20-29 yr, randomly drawn from the Danish Central Personal Registry. Adiponectin was assessed using an in-house assay, and IR was determined using HOMA. Central fat mass (CFM) and lower extremity fat mass (LEFM) was measured by dual-energy x-ray absorptiometry, and visceral adipose tissue (VAT), scadipose tissue (SAT), and thigh fat area (TFA) were assessed by magnetic resonance imaging.Results: Using multiple linear regression analysis, adiponectin correlated negatively with CFM (r = -0.27; P < 0.001) and SAT (r = -0.20; P < 0.001) and positively with LEFM (r = 0.19; P < 0.001) and TFA (r = 0.18; P < 0.001), whereas VAT did not associate significantly. In multiple linear regression analysis, HOMA-IR (dependent variable), correlated significantly with CFM (r = 0.27; P < 0.001) and SAT (r = 0.15; P < 0.001), whereas LEFM, VAT, or TFA did not correlate. Adiponectin was an independent predictor of HOMA-IR in both analyses (r = -0.14; P < 0.001).Conclusion: SAT rather than VAT was inversely associated with adiponectin levels, and, interestingly, fat on the lower extremities was positively associated with adiponectin. Focusing on insulin resistance, SAT rather than VAT and TFA independently predicted a higher HOMA-IR. The observation that adiponectin was independently associated with lower HOMA-IR must be repeated in other populations. (J Clin Endocrinol Metab 94: 4010-4015, 2009)