Oscillatory firing and interneuronal correlations in squirrel monkey striate cortex
Oscillatory firing and interneuronal correlations in squirrel monkey striate cortex
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DOI：
10.1152/jn.1996.75.6.2467
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发表时间：
1996-06-01
影响因子：
2.5
通讯作者：
Livingstone, MS
中科院分区：
文献类型：
--
作者：
Livingstone, MS
1.这项工作探索了大脑可能用于连接相关感知的机制。有人提出，神经元放电的时间关系在表明激活这些神经元的刺激在外部世界中是如何相关的方面可能是重要的。这种时间关系不能用传统的感受野映射来观察，而需要互相关和自相关分析.在猫和猕猴中，具有相似感受野特性的细胞即使在它们的感受野不重叠时也显示出相关的放电。在这里，我报告说，在松鼠猴中，就像在猫中一样，间隔小于或等于5 mm的细胞对可以显示相关的放电，并且当它们受到单一轮廓刺激时，细胞对之间的这种相关性往往更强。这表明，相关性不仅反映了具有相似感受野的细胞之间的永久连接，而且还可能编码了激活刺激是连续的或单个物体的一部分的信息。我还发现，与其他一些关于猴子实验的报道相反，猫的相关放电通常是有节奏的。这些记录进一步表明，节律性的周期性与更强的神经元间同步性有关，这与循环反馈回路参与产生两者的假设一致。在同一皮质柱中，但在不同深度的成对细胞也显示出相关的放电，但在层与层之间的时间差为几毫秒。这对于2/3层内不同深度的细胞和不同层中的细胞对（2/3与4 B或4C α）都是如此，为大细胞流和小细胞流之间的串扰提供了证据。
1. This work explores a mechanism that the brain may use for linking related percepts. It has been proposed that temporal relationships in the firing of neurons may be important in indicating how the stimuli that activate those neurons are related in the external world. Such temporal relationships cannot be seen with conventional receptive field mapping but require cross-correlation and auto-correlation analysis.2. In the cat and the macaque monkey, cells with similar receptive field properties show correlated firing even when their receptive fields do not overlap. Here I report that in the squirrel monkey, as in the cat, pairs of cells less than or equal to 5 mm apart can show correlated firing, and these correlations between pairs of cells are often stronger when they are stimulated by a single contour. This suggests that the correlations reflect not only permanent connections between cells with similar receptive fields, but in addition may encode information that the activating stimuli are continuous or part of a single object. I also find that, as in the cat, and contrary to some other reports on experiments in monkeys, the correlated firing is often rhythmic. These recordings further indicate that peri ods of rhythmicity are associated with stronger interneuronal syn chrony, which is consistent with the hypothesis that recurrent feedback loops are involved in generating both.3. Pairs of cells in the same cortical column, but at different depths also showed correlated firing, but with several milliseconds difference in timimg between layers. This was true for cells at different depths within layer 2/3 and for pairs of cells in different layers (2/3 vs. 4B or 4C alpha), providing evidence for cross-talk between the magno- and parvocellular streams.