Synergistic performance of cyclodextrin-agar hydrogels for ciprofloxacin delivery and antimicrobial effect
Synergistic performance of cyclodextrin-agar hydrogels for ciprofloxacin delivery and antimicrobial effect
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DOI：
10.1016/j.carbpol.2011.03.042
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发表时间：
2011-07-01
影响因子：
11.2
通讯作者：
Alvarez-Lorenzo, Carmen
中科院分区：
文献类型：
--
作者：
Blanco-Fernandez, Barbara;Lopez-Viota, Margarita;Alvarez-Lorenzo, Carmen
环糊精（CD）和琼脂的组合可以通过形成包合复合物和/或离子键来提供与药物相互作用的水凝胶。在50 ℃下，将含或不含琼脂（高达1.5%）的碱性溶液中的羟丙基-β-环糊精和甲基-β-环糊精（20%）与乙二醇二缩水甘油醚交联。琼脂增加硬度、可压缩性和变形模量，但不干扰对CD具有高亲和力的探针（3-甲基苯甲酸）的加载和释放。琼脂显著促进了环丙沙星的负载，并赋予水凝胶在水介质中保留药物的能力。释放可以由离子或pH值的变化触发，导致12小时的持续递送。加载和释放曲线进行了比较，麦芽糖糊精为基础的水凝胶，和CD和琼脂阐明的贡献。用革兰氏阴性和革兰氏阳性细菌进行的微生物测试证实了“绿色”CD-琼脂水凝胶用于开发具有可调物理和药物装载/释放特性的药物递送系统的适用性。(C)2011爱思唯尔有限公司版权所有。
Combination of cyclodextrins (CDs) and agar may render hydrogels that interact with drugs by forming inclusion complexes and/or ionic bonds. Hydroxypropyl-beta-cyclodextrin and methyl-beta-cyclodextrin (20%) in alkaline solutions containing or not agar (up to 1.5%) were cross-linked with ethyleneglycol diglycidylether at 50 degrees C. Agar increases hardness, compressibility and modulus of deformability, but does not interfere in the loading and release of a probe (3-methyl benzoic acid) with high affinity for CD. Agar notably promoted the loading of the zwitterion ciprofloxacin and endowed the hydrogels with ability to retain the drug in water medium. The release can be triggered by ions or changes in pH, leading to a 12-h sustained delivery. Loading and release profiles were compared to those of maltodextrin-based hydrogels, and the contribution of CDs and agar elucidated. Microbiological tests with Gram-negative and Gram-positive bacteria confirmed the suitability of the "green" CD-agar hydrogels for the development of drug delivery systems with tunable physical and drug loading/release properties. (C) 2011 Elsevier Ltd. All rights reserved.