The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.
The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.
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CD103 (αEβ7 整合素) 信号在组织驻留淋巴细胞中的多功能性质。
DOI：
10.1152/ajpcell.00338.2022
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Edelblum,KarenL
中科院分区：
文献类型：
--
作者：
Xu,Weili;Bergsbaken,Tessa;Edelblum,KarenL
肠道组织驻留淋巴细胞对于维持粘膜屏障和预防肠道感染至关重要。这些淋巴细胞的活化必须受到严格调控，以防止在自身免疫性疾病中观察到的异常炎症和上皮损伤，同时也确保抗微生物宿主防御保持不受损害。组织驻留淋巴细胞表达CD 103或αE整联蛋白，其与β7亚基二聚化以结合上皮细胞上表达的E-钙粘蛋白。虽然CD 103在淋巴细胞归巢和滞留于外周组织中的作用已经得到了很好的表征，但CD 103参与后激活的分子信号仍然研究不足。在这里，我们强调了最近的研究，阐明了CD 103在各种淋巴细胞亚群中的功能贡献，无论是作为一个独立的信号分子或在TCR共刺激的背景下。最后，我们将讨论我们对CD 103生物学的理解和靶向CD 103对组织驻留淋巴细胞的治疗潜力的差距。
Intestinal tissue-resident lymphocytes are critical for maintenance of the mucosal barrier and to prevent enteric infections. The activation of these lymphocytes must be tightly regulated to prevent aberrant inflammation and epithelial damage observed in autoimmune diseases, yet also ensure that antimicrobial host defense remains uncompromised. Tissue-resident lymphocytes express CD103, or αE integrin, which dimerizes with the β7 subunit to bind to E-cadherin expressed on epithelial cells. Although the role of CD103 in homing and retention of lymphocytes to and within peripheral tissues has been well characterized, the molecular signals activated following CD103 engagement remain understudied. Here, we highlight recent studies that elucidate the functional contribution of CD103 in various lymphocyte subpopulations, either as an independent signaling molecule or in the context of TCR co-stimulation. Finally, we will discuss the gaps in our understanding of CD103 biology and the therapeutic potential of targeting CD103 on tissue-resident lymphocytes.