DEPENDENCE OF MUTATION FREQUENCY ON RADIATION DOSE RATE IN FEMALE MICE.
DEPENDENCE OF MUTATION FREQUENCY ON RADIATION DOSE RATE IN FEMALE MICE.
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雌性小鼠突变频率对辐射剂量率的依赖性。
DOI：
10.1073/pnas.45.1.18
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发表时间：
1959
影响因子：
11.1
通讯作者：
M. Cupp
中科院分区：
文献类型：
--
作者：
W. Russell;L. B. Russell;M. Cupp
女性急性照射后的特异性基因座突变率明显高于慢性照射后。由于成年小鼠卵巢的条件是不太可能出现次要因素的并发症，因此可以得出结论，在卵母细胞中，突变过程本身存在剂量率效应。剂量RATC对精原细胞照射后突变频率的影响，早先被证实，可能是由于次要因素，现在根据卵母细胞的结果，也被认为是由于对突变过程的剂量率效应。从人类危害的角度来看，结果的最显著特征是，第一，目前没有证据表明女性比男性更不敏感，第二，突变频率与辐射剂量率的相关性的发现适用于对人类危害至关重要的生殖细胞阶段，目前已从男性扩展到女性。(身份验证)
The specific locus mutation rate in females is significantly higher following acute than following chronic irradiation. Since conditions in the adult mouse ovary are such that complications from secondary factors are unlikely, it can be concluded that in oocytes there is a dose-rate effect on the mutation process itself. The influence of dose ratc on the frequency of mutations following irradiation of spermatogonia, which was demonstrated earlier and which could have been due to secondary factors, is now, in the light of the oocyte results, also considered to be due to a dose-rate effect on the mutation process. The most significant features of the results, from the point of view of human hazards, are, first, that there is, at present, no evidence that females are less sensitive than males and, second, that the finding of a dependence of mutation frequency on radiation dose rate, now extended from males to females, applies to those germ cell stages that are important in human hazards. (auth)