Evidence of hepatitis E virus transmission by renal graft
Evidence of hepatitis E virus transmission by renal graft
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DOI：
10.1111/tid.12624
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Peltier, Julie
中科院分区：
文献类型：
--
作者：
Pourbaix, Annabelle;Ouali, Nacera;Peltier, Julie
戊型肝炎病毒（HEV）可在免疫功能低下的患者，特别是实体器官移植受者中引起慢性感染，并可演变为肝硬化。已知几种传播模式。在这里，我们描述了头两个案件，据我们所知，戊型肝炎病毒感染传播的肾移植从同一感染的捐助者，导致慢性肝炎。因此，应考虑通过HEV血清学和聚合酶链反应检测HEV RNA对供体进行系统筛查，特别是在流行地区。
Hepatitis E virus (HEV) can cause chronic infection among immunocompromised patients, especially solid organ transplant recipients, and can evolve to cirrhosis. Several modes of transmission are known. Here we describe the first two cases, to our knowledge, of HEV infection transmitted by a kidney graft from the same infected donor that led to chronic hepatitis. Consequently, systematic screening of donors by HEV serology and HEV RNA detection by polymerase chain reaction, particularly in endemic regions, should be considered.