STRESS-INDUCED HYPERTHERMIA IN MICE - HORMONAL CORRELATES
STRESS-INDUCED HYPERTHERMIA IN MICE - HORMONAL CORRELATES
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DOI：
10.1016/0031-9384(94)90237-2
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发表时间：
1994-10-01
影响因子：
2.9
通讯作者：
OLIVIER, B
中科院分区：
文献类型：
--
作者：
GROENINK, L;VANDERGUGTEN, J;OLIVIER, B
在应激诱导的高温（SIH）范例中，当每只小鼠的温度以1分钟的间隔连续测量时，最后测量的小鼠的直肠温度比第一次测量的温度高约1.5 ℃。在本研究中，证明了SIH伴随着血浆ACTH、皮质酮、并且葡萄糖水平返回基线或多或少与温度平行。温度和血浆应激激素的同时增加强烈支持在小鼠中使用SIH范例作为动物模型来研究药物的推定抗应激或抗焦虑特性。
In the stress-induced hyperthermia (SIH) paradigm in group-housed male mice, the rectal temperature of last measured mice is approximately 1.5 degrees C higher than the first measured one when the temperature of each mouse is measured sequentially with an interval of 1 min. In the present study it is demonstrated that SIH is accompanied by increases in plasma ACTH, corticosterone, and glucose levels that return to baseline more or less parallel to the temperature. The simultaneous increases in temperature and plasma stress hormones strongly support the use of the SIH paradigm in mice as an animal model to study putative anti-stress or anxiolytic properties of drugs.