Increased pre-SMA activation in early PD patients during simple self-initiated hand movements
Increased pre-SMA activation in early PD patients during simple self-initiated hand movements
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DOI：
10.1007/s00415-005-0956-z
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发表时间：
2006-02-01
影响因子：
6
通讯作者：
Rotte, M
中科院分区：
文献类型：
--
作者：
Eckert, T;Peschel, T;Rotte, M
运动迟缓是帕金森病的主要症状之一。这种症状可能是由于PD患者无法最大限度地提高内部驱动运动的速度。近中运动前区，特别是前补充运动区（前SMA）似乎在人类和动物运动的时间启动中起着至关重要的作用。然而，这种激活似乎是有争议的成像研究的PD患者。我们进行了一个运动范式与时间自我发起的运动9初发帕金森病患者开始多巴胺能药物治疗前后。主要发现是与年龄匹配的健康对照受试者相比，初治PD患者的前SMA激活增加。该结果表明SMA前体在自发运动的暂时启动和PD的疾病病理学中的贡献。PD患者的双侧上级小脑激活增加，主要在同侧，同侧下小脑激活减少。这些发现为PD患者小脑的激活模式提供了新的见解。
The slowness of movement, termed bradykinesia, is one of the main symptoms of Parkinson's disease (PD). This symptom may be due to the inability of PD patients to maximise the speed of internally driven movements. The mesial premotor areas and in particular the pre-supplementary motor area (pre-SMA) seem to play a crucial role in the temporal initiation of movements in humans and animals. However, this activation seems to be debatable in imaging studies of PD patients. We performed a motor paradigm with temporally self-initiated movements in nine de novo PD patients before and after initiation of dopaminergic medication. The main finding was an increased activation of the pre-SMA in de novo PD patients compared with healthy age-matched control subjects. This result indicates the contribution of the pre-SMA in the temporal initiation of self-generated movements and in the disease pathology of PD. Increased bilateral activation of the superior cerebellum, mainly on the ipsilateral side, and a decreased activation of the ipsilateral inferior cerebellum in PD patients were also present. These findings provide new insights into the activation pattern of the cerebellum in PD patients.