Viral-induced leukocyte interferon in vesicle fluid from lesions of recurrent herpes labialis.
Viral-induced leukocyte interferon in vesicle fluid from lesions of recurrent herpes labialis.
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复发性唇疱疹病变囊泡液中病毒诱导的白细胞干扰素。
DOI：
10.1093/infdis/143.4.543
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Green,JA
中科院分区：
文献类型：
--
作者：
OverallJr,JC;Spruance,SL;Green,JA
抗病毒活性的特点是人干扰素（HuIFN）被证明在水泡液从19例健康患者中的18例复发性唇疱疹病变。高滴度（几何平均值，20，200单位）出现在病变发展的早期过程中。在接受检测的8例患者中，囊泡液中的抗病毒活性被白细胞（I型）HuIFN-α（HuIFN-α）抗体中和。提示复发性唇疱疹局部皮损中存在HuIFN-α。HuIFN可能在复发性疱疹病毒感染的发病机制中起作用。
Antiviral activity characterized as human interferon (HuIFN) was demonstrated in vesicle fluid from lesions of recurrent herpes labialis in 18 of 19 otherwise healthy patients. High titers (geometric mean, 20,200 units) were present during the early course of lesion development. Antiviral activity in vesicle fluid was neutralized by antibody to leukocyte (type I) HuIFN (HuIFN-α) in the eight patients in whom it was tested. These results indicate that HuIFN-α is present in the local lesions of recurrent herpes labialis. HuIFN may have a role in the pathogenesis of recurrent herpesvirus infections.