Synthesis of optically active .beta.-lactams by the photolytic reaction of imines with optically active chromium carbene complexes. 2. Synthesis of 1-carbacephalothin and 3-ANA relays
Synthesis of optically active .beta.-lactams by the photolytic reaction of imines with optically active chromium carbene complexes. 2. Synthesis of 1-carbacephalothin and 3-ANA relays
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通过亚胺与光学活性铬卡宾络合物的光解反应合成光学活性β-内酰胺。
DOI：
10.1021/jo00046a030
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
L. Hegedus
中科院分区：
文献类型：
--
作者：
Y. Narukawa;K. Juneau;Daniel C. Snustad;D. Miller;L. Hegedus
通过光学活性铬碳络合物 1 与官能化亚胺 2 的光化学反应，以适度的产率和高立体选择性制备了光学活性 1-碳头孢噻吩 (4) 的中继 (3)。相比之下，碳碳络合物 1 与亚胺前体 15a,b 与诺卡霉素的光化学反应的立体选择性要低得多。
A relay (3) to optically active 1-carbacephalothin (4) was prepared in modest yield with high stereoselectivity by the photochemical reaction of optically active chromium carben complex 1 with functionalized imine 2. In contrast, the photochemical reaction of carben complex 1 with imine precursors 15a,b to the nocardicins was much less stereoselective