A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner
A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner
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DOI：
10.1002/ptr.4989
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发表时间：
2014-02-01
影响因子：
7.2
通讯作者：
Fallon, Padraic G.
中科院分区：
文献类型：
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作者：
Aviello, Gabriella;Amu, Sylvie;Fallon, Padraic G.
炎症性肠病是发达国家发病率较高的紧迫公共卫生问题。生活方式或饮食干预的改变可能会减轻疾病进展并提高当前疗法的疗效。在这里，我们在临床相关的自发性小肠结肠炎模型白细胞介素 (IL)-10(-/-) 小鼠中测试了长期补充红海藻矿物质提取物（富含钙 (34%)、镁、磷、硒和其他微量矿物质）的效果。从3至4周龄开始，将矿物质提取物加入到C57BL/6J和BALB/c品系背景的Il10(-/-)小鼠的饮用水中，持续25周。矿物质提取物改善了 C57BL/6J 背景下 Il10(-/-) 小鼠结肠炎的自发发展和疾病的严重程度。矿物提取物处理的Il10(-/-) C57BL/6J品系小鼠显着降低了死亡率、血清淀粉样蛋白A的循环水平并减少了结肠组织损伤。相比之下，用矿物质提取物对 BALB/c 背景下的 Il10(-/-) 小鼠进行类似的治疗并没有改变结肠炎的病程。这些数据表明，长期补充天然矿物质提取物可选择性地改善 C57BL/6J 上的 Il10(-/-) 小鼠的自发性轻度至中度结肠炎，但不会减轻 BALB/c 品系动物中的更中度至重度结肠炎。版权所有 (c) 2013 John Wiley & Sons, Ltd.
Inflammatory bowel disease is an urgent public health problem with a high incidence in developed countries. Alterations of lifestyle or dietary interventions may attenuate the disease progression and increase the efficacy of current therapies. Here we tested the effect of chronic supplementation with a mineral extract from red marine algae - rich in calcium (34%), magnesium, phosphorus, selenium and other trace minerals - in a clinically relevant model of spontaneous enterocolitis, interleukin (IL)-10(-/-) mice. The mineral extract was administered in the drinking water of Il10(-/-) mice on C57BL/6J and BALB/c strain backgrounds for 25weeks commencing from 3 to 4weeks of age. The mineral extract ameliorated the spontaneous development of colitis and severity of disease in Il10(-/-) mice on a C57BL/6J background. Mineral extract-treated Il10(-/-) C57BL/6J strain mice had significantly reduced mortality, circulating levels of serum Amyloid A and reduced colonic tissue damage. In contrast, comparable treatment of Il10(-/-) mice on a BALB/c background with the mineral extract did not alter the course of colitis. These data demonstrate that chronic supplementation with a natural mineral extract selectively ameliorates spontaneous mild-moderate colitis in Il10(-/-) mice on a C57BL/6J, but does not attenuate more moderate-severe colitis in BALB/c strain animals. Copyright (c) 2013 John Wiley & Sons, Ltd.