Adiponectin is related to CD146, a novel marker of endothelial cell activation/injury in chronic renal failure and peritoneally dialyzed patients
Adiponectin is related to CD146, a novel marker of endothelial cell activation/injury in chronic renal failure and peritoneally dialyzed patients
复制标题
DOI：
10.1210/jc.2004-0387
复制
发表时间：
2004-09-01
影响因子：
5.8
通讯作者：
Mysliwiec, M
中科院分区：
文献类型：
--
作者：
Malyszko, J;Malyszko, JS;Mysliwiec, M
脂联素具有抗动脉粥样硬化的特性，可减轻内皮炎性反应。CD146是一种定位于内皮细胞连接的新型细胞黏附分子。在肾功能衰竭中，内皮功能障碍和动脉粥样硬化几乎是普遍存在的。我们研究了脂联素、CD146和其他内皮细胞损伤标志物在接受保守治疗的慢性肾功能衰竭(CRF)患者和接受慢性非卧床腹膜透析(CAPD)的糖尿病肾病患者中的可能相关性。我们检测了脂联素、组织因子途径抑制物(TFPI)、纤溶酶原激活物抑制物(PAI-1)、凝血酶激活纤溶抑制物(PAI-1)和内皮功能/损伤标志物：von Willebrand因子、血栓调节蛋白、血管细胞黏附分子(VCAM)、细胞间黏附分子和CD146。在非糖尿病患者的CAPD中，它与PAI-1、凝血酶激活的纤溶抑制物、细胞间黏附分子、VCAM和CD146显著相关。糖尿病患者CAPD脂联素与C146、VCAM呈正相关，与PAI、TFPI呈负相关。在多元回归分析中，在所有CAPD患者中，只有CD146仍然是脂联素的阳性预测因子。在CRF中，脂联素与CD146相关。在健康志愿者中，脂联素与TFPI和CD146相关。CD146相关的脂联素升高可能是一种逆调节反应的表达，目的是减轻肾功能衰竭时血管内皮细胞损伤和增加心血管风险的后果。
Adiponectin has antiatherogenic properties and attenuates endothelial inflammatory responses. CD146 is a novel cell adhesion molecule localized at the endothelial junction. In renal failure, endothelial dysfunction and atherosclerosis are almost universal. We studied possible correlations between adiponectin, CD146, and other markers of endothelial cell injury in patients with chronic renal failure (CRF) on conservative treatment and patients with and without diabetic nephropathy maintained on chronic ambulatory peritoneal dialysis ( CAPD).We assessed adiponectin, tissue factor pathway inhibitor ( TFPI), plasminogen activator inhibitor (PAI-1), thrombin-activatable fibrinolysis inhibitor, and endothelial function/ injury markers: von Willebrand factor, thrombomodulin, vascular cell adhesion molecule ( VCAM), intercellular adhesion molecule, and CD146.Adiponectin was elevated in patients with CRF and on CAPD. It correlated significantly, with PAI-1, thrombin-activatable fibrinolysis inhibitor, intercellular adhesion molecule, VCAM, and CD146 in nondiabetics on CAPD. In diabetics, CAPD adiponectin correlated positively with C146 and VCAM and negatively with PAI and TFPI. In multivariate regression analysis, only CD146 remained a positive predictor of adiponectin in all CAPD patients. In CRF, adiponectin correlated with CD146. In healthy volunteers, adiponectin correlated with TFPI and CD146.Elevated adiponectin related to CD146 may be the expression of a counterregulatory response aimed at mitigating the consequences in endothelial damage and increased cardiovascular risk in renal failure.