High Wall Shear Stress can Predict Wall Degradation in Ascending Aortic Aneurysms: An Integrated Biomechanics Study.
High Wall Shear Stress can Predict Wall Degradation in Ascending Aortic Aneurysms: An Integrated Biomechanics Study.
复制标题
DOI：
10.3389/fbioe.2021.750656
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Athanasiou T
中科院分区：
文献类型：
--
作者：
Salmasi MY;Pirola S;Sasidharan S;Fisichella SM;Redaelli A;Jarral OA;O'Regan DP;Oo AY;Moore JE Jr;Xu XY;Athanasiou T
背景：血流模式可通过血管壁重塑改变胸升主动脉瘤（ATAA）的材料特性。本研究探讨了壁面剪应力（WSS）之间的关系，从基于图像的计算建模与组织衍生的机械和微结构性能的ATAA壁，使用分段分析。 方法：10例ATAA患者接受手术治疗。排除：双尖瓣退行性变、结缔组织病。所有患者术前均进行了四维血流磁共振成像（4D-MRI），允许进行患者特定的计算流体动力学（CFD）分析和ATAA区域的解剖学精确WSS标测（每例患者6-12个节段）。从手术中获得ATAA样本，并对其进行区域特定拉伸和剥离试验（与WSS节段匹配）。计算病理学用于表征弹性蛋白/胶原蛋白丰度和平滑肌细胞（SMC）计数。 结果如下：WSS值升高可预测：壁厚减小[系数−0.0489，95% CI（−0.0905，−0.00727），p = 0.022]和夹层能量功能（纵向）[− 15，0，95% CI（−33.00，−2.98），p = 0.048]。高WSS值也预测了较高的极限抗拉强度[系数0.136，95% CI（0.001，0.270），p = 0.048]。此外，WSS升高还可预测弹性蛋白水平降低[coef −0.276，95%（CI −0.531，−0.020），p = 0.035]和SMC计数降低[coef −6.19，95% CI（−11.41，−0.98），p = 0.021]。发现WSS对胶原蛋白丰度或周向机械性能没有影响。 结论：我们的研究表明，ATAA疾病中WSS值升高与主动脉壁退化之间存在相关性。进一步的研究可能有助于确定预测急性主动脉事件的阈值。
Background: Blood flow patterns can alter material properties of ascending thoracic aortic aneurysms (ATAA) via vascular wall remodeling. This study examines the relationship between wall shear stress (WSS) obtained from image-based computational modelling with tissue-derived mechanical and microstructural properties of the ATAA wall using segmental analysis. Methods: Ten patients undergoing surgery for ATAA were recruited. Exclusions: bicuspid aortopathy, connective tissue disease. All patients had pre-operative 4-dimensional flow magnetic resonance imaging (4D-MRI), allowing for patient-specific computational fluid dynamics (CFD) analysis and anatomically precise WSS mapping of ATAA regions (6–12 segments per patient). ATAA samples were obtained from surgery and subjected to region-specific tensile and peel testing (matched to WSS segments). Computational pathology was used to characterize elastin/collagen abundance and smooth muscle cell (SMC) count. Results: Elevated values of WSS were predictive of: reduced wall thickness [coef −0.0489, 95% CI (−0.0905, −0.00727), p = 0.022] and dissection energy function (longitudinal) [−15,0, 95% CI (−33.00, −2.98), p = 0.048]. High WSS values also predicted higher ultimate tensile strength [coef 0.136, 95% CI (0 0.001, 0.270), p = 0.048]. Additionally, elevated WSS also predicted a reduction in elastin levels [coef −0.276, 95% (CI −0.531, −0.020), p = 0.035] and lower SMC count ([oef −6.19, 95% CI (−11.41, −0.98), p = 0.021]. WSS was found to have no effect on collagen abundance or circumferential mechanical properties. Conclusions: Our study suggests an association between elevated WSS values and aortic wall degradation in ATAA disease. Further studies might help identify threshold values to predict acute aortic events.
登录
查看更多内容
基于 4-D 流 MRI 的患者特异性主动脉夹层血流计算分析
影响因子：
4.6
作者：
Pirola, Selene;Guo, Baolei;Xu, Xiao Yun
通讯作者：
Xu, Xiao Yun
DOI：
10.1186/1532-429x-14-84
发表时间：
2012-12-13
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Bürk J;Blanke P;Stankovic Z;Barker A;Russe M;Geiger J;Frydrychowicz A;Langer M;Markl M
通讯作者：
Markl M
影响因子：
39.3
作者：
Erbel, Raimund;Aboyans, Victor;Vrints, Christiaan J. M.
通讯作者：
Vrints, Christiaan J. M.
影响因子：
2.4
作者：
Morbiducci, Umberto;Ponzini, Raffaele;Rizzo, Giovanna
通讯作者：
Rizzo, Giovanna
影响因子：
20.1
作者：
Humphrey JD;Schwartz MA;Tellides G;Milewicz DM
通讯作者：
Milewicz DM