Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice
Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice
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DOI：
10.1128/jvi.72.4.2630-2637.1998
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发表时间：
1998-04-01
影响因子：
5.4
通讯作者：
Chisari, FV
中科院分区：
文献类型：
--
作者：
Cavanaugh, VJ;Guidotti, LG;Chisari, FV
我们先前已经证明，HBV转基因小鼠肝脏中的B型肝炎病毒（HBV）复制和基因表达被细胞毒性T淋巴细胞（CTL）和淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染（触发肝脏中α/β干扰素、γ干扰素和肿瘤坏死因子α产生的刺激）消除，我们现在报道，在腺病毒和鼠巨细胞病毒（MCMV）诱导的肝炎期间，肝HBV复制和基因表达被这些细胞因子的局部诱导抑制。我们发现MCMV还通过引起间质性肾炎和在肾实质中诱导相同的细胞因子来阻断HBV在肾近曲小管中的复制和基因表达。这些结果表明，炎症细胞因子可能有助于在人类急性病毒性肝炎的病毒清除，他们意味着，这些细胞因子在肝脏和慢性感染患者的其他感染组织中的诱导可能具有治疗价值。
We have previously demonstrated that hepatitis B virus (HBV) replication and gene expression are abolished in the livers of HBV transgenic mice by cytotoxic T lymphocytes (CTLs) and during lymphocytic choriomeningitis virus (LCMV) infection, stimuli that trigger the production of alpha/beta interferon, gamma interferon, and tumor necrosis factor alpha in the liver, We now report that hepatic HBV replication and gene expression are inhibited by the local induction of these cytokines during adenovirus-and murine cytomegalovirus us (MCMV)-induced hepatitis, Further, we show that MCMV also blocks HBV replication and gene expression in the proximal convoluted tubules of the kidney by causing interstitial nephritis and inducing the same cytokines in the renal parenchyma. These results suggest that inflammatory cytokines probably contribute to viral clearance during acute viral hepatitis in humans, and they imply that induction of these cytokines in the liver and other infected tissues of chronically infected patients might have therapeutic value.