Anthrax toxin delivers a one-two punch.
Anthrax toxin delivers a one-two punch.
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DOI：
10.1016/j.chom.2010.10.011
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发表时间：
2010-11-18
影响因子：
30.3
通讯作者：
LeVine SM
中科院分区：
文献类型：
--
作者：
Bradley KA;LeVine SM
尽管50多年前就被确定为炭疽芽孢杆菌的主要毒力因子，但确定炭疽毒素的生理相关靶标一直是具有挑战性的。刘等人。证明髓系细胞中毒有助于建立感染，但不是与终末期疾病相关的高浓度毒素引起的死亡所必需的。
Although identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets of anthrax toxin has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection, but is not required for mortality resulting from high toxin concentrations associated with end-stage disease.