VIRUSES OF ENTAMOEBA-HISTOLYTICA .1. IDENTIFICATION OF TRANSMISSIBLE VIRUS-LIKE AGENTS
VIRUSES OF ENTAMOEBA-HISTOLYTICA .1. IDENTIFICATION OF TRANSMISSIBLE VIRUS-LIKE AGENTS
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DOI：
10.1128/jvi.9.2.326-341.1972
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发表时间：
1972-01-01
影响因子：
5.4
通讯作者：
MATTERN, CFT
中科院分区：
文献类型：
--
作者：
DIAMOND, LS;BARTGIS, IL;MATTERN, CFT
本文和另一篇报告讨论了溶组织内阿米巴（Entamoeba histolytica）的鉴别和形态发生。可能有两种不同类型的病毒在不同的阿米巴菌株中产生不同的病理图像，或者，不太可能，有一种类型的病原体在不同的溶组织内阿米巴菌株中具有广泛不同的形态和形态发生图像。这两种类型的试剂在axenized阿米巴中产生溶解反应，并且已经连续传代到确保其复制性质的程度。其中一种似乎在细胞核中复制为多簇细丝，最终裂解细胞核，导致细胞死亡。第二种类型的代理似乎是一个典型的多面体病毒，只在细胞质中看到，也导致细胞裂解。在产生核病变的试剂的后期传代中也发现了与第二种试剂形态学上不可区分的颗粒。
This and a companion report deal with the identification and morphogenesis of viruses in axenized cultures ofEntamoeba histolytica.There are probably two different types of virus each producing a different pathological picture in different amoebal strains, or, less likely, there is one type of agent having widely different morphological and morphogenetical pictures in different strains ofE. histolytica.Both types of agent produce a lytic response in axenized amoebae and have been serially passaged to an extent assuring their replicating nature. One appears to replicate in the nucleus as multiple clusters of fine filaments which ultimately lyse the nucleus, causing cell death. The second type of agent appears to be a typical polyhedral virus, seen only in the cytoplasm and also resulting in lysis of the cell. A particle morphologically indistinguishable from this second agent is also found in late passages of the agent producing the nuclear pathology.