SENSORY NEUROANATOMY OF A SKIN-PENETRATING NEMATODE PARASITE - STRONGYLOIDES-STERCORALIS .1. AMPHIDIAL NEURONS
SENSORY NEUROANATOMY OF A SKIN-PENETRATING NEMATODE PARASITE - STRONGYLOIDES-STERCORALIS .1. AMPHIDIAL NEURONS
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DOI：
10.1002/cne.903570208
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发表时间：
1995-06-26
影响因子：
2.5
通讯作者：
SCHAD, GA
中科院分区：
文献类型：
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作者：
ASHTON, FT;BHOPALE, VM;SCHAD, GA
粪类圆线虫感染性幼虫恢复进食和发展收到的信号，可能是化学，从主机。这种幼虫只有两个前感觉器官对外界环境开放。这些大的、成对的高脚杯状感受器，被称为端生体，因此可能是唯一的化学感受器。利用连续电子显微照片的三维重建，研究了双角体结构。在每一个两栖类，纤毛状树突状进程的11个神经元延伸近的amphidial孔;第十二终止于基地的amphidial通道，后面的阵列的横向预测的其他进程。一个特殊的树突状突起离开端生鞘通道，形成一个与端生鞘细胞的片层交错的片层复合体。这种“板层细胞”类似于秀丽隐杆线虫的一种“翼细胞”或可能是“指细胞”。13个两足类神经元中的每一个都被追踪到其细胞体。包括板层细胞在内的10个神经元与神经环后方的外侧神经节中的胞体相连。这些胞体的位置与C.优雅因此，它们被命名为使用C。优雅命名法其他三个两足突连接到神经环前的细胞体;这些在C中没有同源物。优雅的绘制了一张能够识别活蠕虫中的双端细胞体的图谱。因此，可以进行激光消融研究，以确定哪些神经元参与感染过程。(C)1995 Wiley-Liss，Inc.
The Strongyloides stercoralis infective larva resumes feeding and development on receipt of signals, presumably chemical, from a host. Only two of the anterior sense organs of this larva are open to the external environment. These large, paired goblet-shaped sensilla, known as amphids, are presumably, therefore, the only chemoreceptors. Using three-dimensional reconstructions made from serial electron micrographs, amphidial structure was investigated. In each amphid, cilialike dendritic processes of 11 neurons extend nearly to the amphidial pore; a twelfth terminates at the base of the amphidial channel, behind an array of lateral projections on the other processes. A specialized dendritic process leaves the amphidial channel and forms a complex of lamellae that interdigitate with lamellae of the amphidial sheath cell. This ''lamellar cell'' is similar to one of the ''wing cells'' or possibly the ''finger cell'' of Caenorhabditis elegans. Each of the 13 amphidial neurons was traced to its cell body. Ten neurons, including the lamellar cell, connect to cell bodies in the lateral ganglion, posterior to the nerve ring. The positions of these cell bodies were similar to those of the amphidial cell bodies in C. elegans. Therefore, they were named by using C. elegans nomenclature. Three other amphidial processes connect to cell bodies anterior to the nerve ring; these have no homologs in C. elegans. A map allowing identification of the amphidial cell bodies in the living worm was prepared. Consequently, laser ablation studies can be conducted to determine which neurons are involved in the infective process. (C) 1995 Wiley-Liss, Inc.