Experimentally induced rhythmic jaw muscle activities during non-rapid eye movement sleep in freely moving guinea pigs.
Experimentally induced rhythmic jaw muscle activities during non-rapid eye movement sleep in freely moving guinea pigs.
复制标题
在自由活动的豚鼠的非快速眼动睡眠期间，通过实验诱导有节奏的下颌肌肉活动。
DOI：
10.1111/jsr.12823
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发表时间：
2019
影响因子：
4.4
通讯作者：
Kato T
中科院分区：
文献类型：
--
作者：
Yamada KI;Higashiyama M;Toyoda H;Masuda Y;Kogo M;Yoshida A;Kato T
在睡眠磨牙症患者的非快速眼动睡眠中，节律性颌肌活动经常发生。本研究旨在探讨动物在非快速眼动睡眠中咀嚼节律产生的反应特征。11只豚鼠在外科手术后植入刺激电极，进行肌电、眼电、脑电和心电的多导描记。在自由活动条件下，对皮质球束施加三种强度的重复电刺激。对二腹肌和咬肌的节律性肌电反应进行评分和分析。对与这些刺激相关的皮质脑电功率和心率的变化进行量化。对皮质球束的微刺激在二腹肌中诱导有节律性的颌肌活动，在清醒和非快速眼动睡眠时偶尔有咬肌活动。与清醒时相比，非快速眼动睡眠时的颌骨节律性肌肉活动的反应率显著降低(P<；0.01)，反应潜伏期显著延长(P<；0.01)。刺激强度越高，反应速度越快，反应潜伏期越短。无论警戒状态和刺激强度如何，二腹肌和咬肌的平均爆发间期相似。在非快速眼动睡眠期间，诱发的颌肌节律性活动之后，增量功率一过性下降，β功率和心率增加。在非快速眼动睡眠中，咀嚼运动系统能够对促进性输入做出反应，向颌部肌肉产生有节奏的输出，尽管响应性因清醒而降低。
Rhythmic jaw muscle activities frequently occur during non‐rapid eye movement sleep in patients with sleep bruxism. The present study aimed to investigate the response characteristics of the masticatory rhythm generation during non‐rapid eye movement sleep in animals. Eleven guinea pigs were surgically prepared for polygraphic recordings by electromyography, electrooculography, electroencephalography and electrocardiography with the implantation of a stimulating electrode. Repetitive electrical microstimulations at three intensities were applied to the corticobulbar tract under freely moving conditions. The rhythmic electro‐myographic responses of the digastric and masseter muscles were scored and analysed. Changes in cortical electro‐encephalographic power and heart rate in association with these stimulations were quantified. Microstimulations to the corticobulbar tract induced rhythmic jaw muscle activities in digastric muscles, occasionally with masseter activities during wakefulness and non‐rapid eye movement sleep. The response rate of rhythmic jaw muscle activities was significantly lower (p< 0.01) and the response latency was significantly longer (p< 0.01) during non‐rapid eye movement sleep than during wakefulness. At higher stimulus intensities, the response rate increased and response latency decreased. The mean burst intervals of the digastric and masseter muscles were similar regardless of vigilance states and stimulus intensities. Induced rhythmic jaw muscle activities during non‐rapid eye movement sleep were followed by a transient decrease in delta power and increases in beta power and heart rate. During non‐rapid eye movement sleep, the masticatory motor system is able to generate rhythmic outputs to the jaw muscles in response to facilitatory inputs although the responsiveness was decreased from wakefulness.