Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
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DOI：
10.1152/jappl.2001.90.6.2157
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Newman, AB
中科院分区：
文献类型：
--
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
尽管肌肉质量的损失被认为是肌肉力量随着衰老而降低的原因，但关于衰老肌肉的组成是否会影响力量，鲜为人知。通过计算机断层扫描确定的骨骼肌衰减系数是对肌肉密度的无创度量，而较低的值反映了肌肉脂质含量的增加。这项调查检查了以下假设：在2,627名男性和女性中，较低的肌肉衰减价值与较低的自愿等肌动力学膝关节伸肌强度有关，年龄在60度 /s中，年龄在70-79岁的男性中，参加了健康ABC研究的基线研究，这是一项健康ABC研究的纵向研究。 ，衰老和身体成分。男性的力量高于女性（132.3 +/- 34.5对81.4 +/- 22.0 N.M，p <0.01）。男性的肌肉衰减值（37.3 6.5 vs. 34.7 +/- 7.0 Hounsfield单位）和肌肉横断面区域（CSA）比女性（132.7 +/- 22.4 vs. 93.3 +/- 17.3 +/- 17.5 cm（2）） ，两者的p <0.01）。男性的每肌CSA强度也更高（1.00 0.21 vs. 0.88 +/- 0.21 N.M.CM（-2））。腿筋的衰减系数明显低于股四头肌（28.7 +/- 8.7 vs. 41.1 +/- 6.9 Hounsfield单位，p <0.01）。最大的男性和女性中，中高的肌肉衰减值最低（p <0.01），并且与总体脂肪呈负相关（r = -0.53，p <0.01）。较高的肌肉衰减值也与更大的特异性产生有关（r = 0.26，p <0.01）。多变量回归分析表明，在调整男性和女性的肌肉CSA和肌肉中脂肪组织后，肌肉的衰减系数与肌肉力量独立相关。这些结果表明，老年人在计算机断层扫描上肌肉的衰减值可以解释不归因于肌肉数量的肌肉力量的差异。
Although loss of muscle mass is considered a cause of diminished muscle strength with aging, little is known regarding whether composition of aging muscle affects strength. The skeletal muscle attenuation coefficient, as determined by computed tomography, is a noninvasive measure of muscle density, and lower values reflect increased muscle lipid content. This investigation examined the hypothesis that lower values for muscle attenuation are associated with lower voluntary isokinetic knee extensor strength at 60 degrees /s in 2,627 men and women aged 70-79 yr participating in baseline studies of the Health ABC Study, a longitudinal study of health, aging, and body composition. Strength was higher in men than in women (132.3 +/- 34.5 vs. 81.4 +/- 22.0 N.m, P < 0.01). Men had greater muscle attenuation values (37.3 6.5 vs. 34.7 +/- 7.0 Hounsfield units) and muscle cross-sectional area (CSA) at the midthigh than women (132.7 +/- 22.4 vs. 93.3 +/- 17.5 cm(2), P < 0.01 for both). The strength per muscle CSA (specific force) was also higher in men (1.00 0.21 vs. 0.88 +/- 0.21 N.m.cm(-2)). The attenuation coefficient was significantly lower for hamstrings than for quadriceps (28.7 +/- 8.7 vs. 41.1 +/- 6.9 Hounsfield units, P < 0.01). Midthigh muscle attenuation values were lowest (P < 0.01) in the eldest men and women and were negatively associated with total body fat (r = -0.53, P < 0.01). Higher muscle attenuation values were also associated with greater specific force production (r = 0.26, P < 0.01). Multivariate regression analysis revealed that the attenuation coefficient of muscle was independently associated with muscle strength after adjustment for muscle CSA and midthigh adipose tissue in men and women. These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity.