Differential effect of prior influenza infection on alveolar macrophage phagocytosis of Staphylococcus aureus and Escherichia coli: involvement of interferon-gamma production
Differential effect of prior influenza infection on alveolar macrophage phagocytosis of Staphylococcus aureus and Escherichia coli: involvement of interferon-gamma production
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DOI：
10.1111/j.1348-0421.2011.00383.x
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发表时间：
2011-11-01
影响因子：
2.6
通讯作者：
Shin, Yeun-Kyung
中科院分区：
文献类型：
--
作者：
Do Thi Thu Hang;Choi, Eun-Jin;Shin, Yeun-Kyung
甲型流感病毒是呼吸道感染的主要原因之一。虽然流感病毒单独感染可导致肺炎，但继发性细菌感染与病毒结合是发病和死亡的主要原因。有趣的是，虽然流感感染增加了对一些细菌的易感性，包括肺炎链球菌、金黄色葡萄球菌（S。金黄色葡萄球菌）和流感嗜血杆菌、其他细菌如大肠杆菌（E. coli）。大肠杆菌）和肺炎克雷伯菌与流感感染无关。这种差异的原因尚不清楚。在这项研究中，发现先前的流感病毒感染抑制小鼠肺泡巨噬细胞吞噬S。aureus而不是E.杆菌在这里，这种抑制的机制是阐明：以前的流感病毒感染强烈增加干扰素γ（IFN-γ）的生产。此外，表明IFN-γ差异性地影响肺泡巨噬细胞对S. aureus和E.杆菌本研究的发现解释了流感病毒感染如何增加对某些细菌的易感性，如S。金黄色葡萄球菌，而不是其他人，并提供证据表明，IFN-γ可能是一个有前途的目标，保护人类人口从继发性细菌感染的流感。
The influenza A virus is one of the main causes of respiratory infection. Although influenza virus infection alone can result in pneumonia, secondary bacterial infection combined with the virus is the major cause of morbidity and mortality. Interestingly, while influenza infection increases susceptibility to some bacteria, including Streptococcus pneumoniae, Staphylococcus aureus (S. aureus), and Haemophilus influenzae, other bacteria such as Escherichia coli (E. coli) and Klebsiella pneumoniae are not associated with influenza infection. The reason for this discrepancy is not known. In this study, it was found that prior influenza virus infection inhibits murine alveolar macrophage phagocytosis of S. aureus but not of E. coli. Here, the mechanism for this inhibition is elucidated: prior influenza virus infection strongly increases interferon gamma (IFN-gamma) production. Furthermore, it was shown that IFN-gamma differentially affects alveolar macrophage phagocytosis of S. aureus and E. coli. The findings of the present study explain how influenza virus infection increases susceptibility to some bacteria, such as S. aureus, but not others, and provides evidence that IFN-gamma might be a promising target for protecting the human population from secondary bacterial infection by influenza.