Induction of oxidative stress by bisphenol A and its pleiotropic effects.
Induction of oxidative stress by bisphenol A and its pleiotropic effects.
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DOI：
10.1002/em.22072
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发表时间：
2017-03
影响因子：
2.8
通讯作者：
Gassman NR
中科院分区：
文献类型：
--
作者：
Gassman NR
双酚A（BPA）已成为公众密切关注的目标，因为人们担心它与肥胖、糖尿病、生殖障碍和癌症等人类疾病的关系。BPA是消费品中一种非常普遍的化学品，人类接触被认为是无处不在的。许多研究已经证明了它的内分泌干扰特性，并将其与细胞毒性，遗传毒性和致癌作用的接触归因于;然而，这些研究的结果仍然存在高度争议，关于BPA的安全性及其在人类疾病中的作用尚未达成共识。其中一个影响因素是缺乏分子机制或作用模式来解释BPA暴露后观察到的多样性和多效性效应。在过去的十年中，BPA研究的增加导致了更多的研究，研究了分子机制，并揭示了BPA诱导的氧化应激与人类疾病之间的联系。在这里，审查目前的文献研究BPA暴露和诱导活性氧（ROS）或氧化应激将提供检查景观目前的BPA文献，并提供一个框架，了解如何诱导氧化应激BPA可能有助于暴露后观察到的多效性效应。
Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exposure with cytotoxic, genotoxic, and carcinogenic effects; however, the results of these studies are still highly debated and a consensus about BPA's safety and its role in human disease has not been reached. One of the contributing factors is a lack of molecular mechanisms or modes of action that explain the diverse and pleiotropic effects observed after BPA exposure. The increase in BPA research seen over the last ten years has resulted in more studies that examine molecular mechanisms and revealed links between BPA-induced oxidative stress and human disease. Here, a review of the current literature examining BPA exposure and the induction of reactive oxygen species (ROS) or oxidative stress will be provided to examine the landscape of the current BPA literature and provide a framework for understanding how induction of oxidative stress by BPA may contribute to the pleiotropic effects observed after exposure.