CsOH-promoted epoxide ring-opening with phosphines: mild and efficient synthesis of monohydroxyphosphines
CsOH-promoted epoxide ring-opening with phosphines: mild and efficient synthesis of monohydroxyphosphines
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DOI：
10.1016/j.tetlet.2003.08.068
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发表时间：
2003-10-06
影响因子：
1.8
通讯作者：
Salvatore, RN
中科院分区：
文献类型：
--
作者：
Fox, DL;Robinson, AA;Salvatore, RN
在室温下，在氢氧化铯、4埃分子筛和 DMF 存在下，使用伯膦或仲膦进行环氧化物开环，实现了温和且方便的单羟基膦合成。发现这些反应条件具有高度区域选择性和立体选择性，仅以中等到高产率产生各种单羟基膦。 (C) 2003 Elsevier Ltd. 保留所有权利。
A mild and convenient synthesis of monohydroxyphosphines has been achieved by epoxide ring-opening using primary or secondary phosphines in the presence of cesium hydroxide, 4 Angstrom molecular sieves and DMF at room temperature. These reaction conditions were found to be highly regio- and stereoselective producing various monohydroxyphosphines exclusively in moderate to high yields. (C) 2003 Elsevier Ltd. All rights reserved.