THE ROLE OF INTERLEUKIN-1ß AND INTERLEUKIN-33 IN ATOPIC DERMATITIS
THE ROLE OF INTERLEUKIN-1ß AND INTERLEUKIN-33 IN ATOPIC DERMATITIS
复制标题
INTERLEUKIN-1β 和 INTERLEUKIN-33 在特应性皮炎中的作用
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
L. Rashed
中科院分区：
文献类型：
--
作者：
R. Hay;N. F. Ibrahim;D. Metwally;L. Rashed
白细胞介素-1超家族是一组在免疫和炎症反应中起调节作用的细胞因子。白细胞介素-33是该家族的一员，已知可诱导T辅助2细胞因子的表达，而T辅助2细胞因子在特应性皮炎中起重要作用。目的：探讨白细胞介素-1和白细胞介素- 33在特应性皮炎患者中作为T辅助因子2诱导因子的表达。材料与方法：本研究包括20例特应性过敏患者和20例表面健康个体作为对照。所有参与者的皮肤活检将通过ELISA技术检测白细胞介素-1和33。结果：患者两种白细胞介素水平均高于对照组（P<0.001）。重度特应症患者白细胞介素-33水平高于轻度和中度特应症患者，差异有统计学意义（P=0.011）。两种白细胞介素在特应性反应中呈显著相关（r=0.632， P=0.003）。结论：这是第一个同时评估白细胞介素-1和白细胞介素- 33在特应性患者中的作用的研究。这两种白细胞介素都可能在特应性皮炎的炎症反应中发挥淋巴细胞募集的作用，并可能成为治疗耐药病例的靶向药物。
Introduction: Interleukin-1 super family is a group of cytokines that play a role in the regulation of immune and inflammatory responses. Interleukin-33 is a member of this family and is known to induce expression of the T helper2 cytokines that are important players in atopic dermatitis. Aim: To evaluate the expression of interleukins-1s and 33 as T helper2 cytokines inducers in patients with atopic dermatitis. Materials and Methods: This study included 20 atopic patients and 20 apparently healthy individuals serving as controls. Skin biopsies from all participants will be examined for detection of interleukins-1s and 33 by ELISA technique. Results: Both interleukins were statistically higher (P<0.001) in patients than in controls. A statistically significant (P=0.011) highest levels of interleukin-33 was detected in severe cases of atopics when compared to mild and moderate cases. A significant correlation (r=0.632, P=0.003) between both interleukins was detected in atopics. Conclusions: This is the first study to evaluate both interleukin-1s and33 together in atopic patients. Both interleukins could play a role in the recruitment of lymphocytes during the inflammatory reaction in atopic dermatitis and could be targeted in the treatment of resistant cases.
影响因子：
15.9
作者：
Hakonarson, H;Maskeri, N;Grunstein, MM
通讯作者：
Grunstein, MM