Biogenesis and function of Porphyromonas gingivalis outer membrane vesicles.
Biogenesis and function of Porphyromonas gingivalis outer membrane vesicles.
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DOI：
10.2217/fmb.15.63
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发表时间：
2015
影响因子：
3.1
通讯作者：
Xie H
中科院分区：
文献类型：
--
作者：
Xie H
牙龈卟啉单胞菌是引起慢性牙周炎的重要致病菌之一。迄今为止检查的所有牙龈卟啉单胞菌菌株都产生外膜囊泡。近年来的研究发现，牙龈卟啉单胞菌囊泡中含有粘附素、毒素和蛋白水解酶等毒力因子。携带其亲本牙龈卟啉单胞菌细胞的大部分特征，囊泡与宿主细胞和微生物生物膜的其他成员通信，导致毒力因子传递到这些宿主细胞中并形成致病菌主导的微生物群落。深入了解囊泡在牙龈卟啉单胞菌致病性中的性质和作用既重要又及时，特别是在谈到牙周炎及其相关的全身效应时。
Porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. All P. gingivalis strains examined thus far produce outer membrane vesicles. Recent studies have found that vesicles possess some well-known virulence factors of P. gingivalis such as adhesins, toxins and proteolytic enzymes. Carrying most of the characteristic features of their parent P. gingivalis cells, vesicles communicate with host cells and other members of microbial biofilms, resulting in the transmission of virulence factors into these host cells and the formation of pathogenic bacteria-dominated microbial communities. An in-depth understanding of both the nature and role of vesicles in the pathogenicity of P. gingivalis is both important and timely, particularly when speaking of periodontitis and its related systemic effects.