CORONARY RESERVE IS DEPRESSED IN POSTMYOCARDIAL INFARCTION REACTIVE CARDIAC-HYPERTROPHY
CORONARY RESERVE IS DEPRESSED IN POSTMYOCARDIAL INFARCTION REACTIVE CARDIAC-HYPERTROPHY
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DOI：
10.1161/01.cir.81.1.238
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发表时间：
1990-01-01
期刊：
影响因子：
37.8
通讯作者：
WICKER, P
中科院分区：
文献类型：
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作者：
KARAM, R;HEALY, BP;WICKER, P
心肌梗死(MI)后，剩余心肌经历代偿性反应性肥厚。尽管在这种情况下，存活心肌的冠脉灌注可以是心功能的重要决定因素，但关于反应性肥厚的心肌血流量还没有可用的数据。因此，在结扎左冠状动脉诱发心肌梗塞4周后，我们使用放射性微球测量了大鼠的冠脉血流量和储备。冠脉最大扩张剂量为12 mg/kg，最大扩张剂量为0.45 mg/kg/min。假手术组大鼠作为对照组。梗死组所有动物均出现大面积心肌梗死，影响左心室30-51%(平均41%)。假手术组大鼠左室舒张末压显著升高(30.±.6.5对8.0.+-.2.5 mm Hg，P
After a myocardial infarction (MI), the remaining myocardium undergoes a compensatory reactive hypertrophy. Although coronary perfusion to the surviving myocardium can be an important determinant of cardiac function in this setting, there are no available data regarding myocardial blood flow in reactive hypertrophy. Accordingly, we measured coronary blood flow and reserve using radioactive microspheres in rats 4 weeks after induction of an MI by ligation of the left coronary artery. Maximal coronary dilation was induced by Carbochrome, a potent coronary vasodilator, infused at a rate of 0.45 mg/kg/min up to a total dose of 12 mg/kg. Sham-operated rats served as controls. All animals in the infarct group and a large MI affecting 30-51% (average, 41%) of the left ventricle. Left ventricular end-diastolic pressure was significantly elevated (30.+-.6.5 vs. 8.0.+-.2.5 mm Hg in sham-operated rats, p