Increased levels of interleukin-6,-8 and-10 are associated with fatal outcome following severe traumatic brain injury
Increased levels of interleukin-6,-8 and-10 are associated with fatal outcome following severe traumatic brain injury
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DOI：
10.3109/02699052.2014.916818
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发表时间：
2014-01-01
期刊：
影响因子：
1.9
通讯作者：
Simon, Daniel
中科院分区：
文献类型：
--
作者：
Brasiliano Ferreira, Luiz Carlos;Regner, Andrea;Simon, Daniel
背景资料：尽管细胞因子的产生与神经创伤有关，但关于细胞因子水平与重型创伤性脑损伤（TBI）临床预后的关系仍存在争议。（IL-1 β、IL-6、IL-8、IL-10、IL-12 p70和TNF-α）与主要结局相关方法：本前瞻性研究纳入了24例男性严重TBI患者。24和48小时后，在重症监护室（ICU）（研究入组）采集静脉血样。结果：重型颅脑损伤患者的死亡率为42%。与对照组相比，TBI患者除IL-1 β外，所有测量的细胞因子水平均显著增加。与在第一个样品（研究进入）和随后的样品（24小时后）中测量的幸存者亚组相比，在非幸存者TBI患者中观察到IL-10、IL-8和IL-6水平的统计学显著增加。在任何时间sample.Conclusions的幸存者和非幸存者之间的IL-1 β，TNF-α和IL-12 p70水平没有显着差异：研究结果表明，增加IL-10，-8和-6水平可能构成严重TBI患者的不利结果的早期预测。
Background: Despite the involvement of cytokine production in neurotrauma, there is still controversy regarding cytokines levels and clinical outcome following severe traumatic brain injury (TBI).Objective: The present study was designed to investigate whether cytokine levels (of IL-1 beta, IL-6, IL-8, IL-10, IL-12p70 and TNF-alpha) are associated with primary outcome (death or survival) after severe TBI.Methods: This prospective study enrolled 24 male patients, victims of severe TBI. Venous blood samples were taken in the Intensive Care Unit (ICU) (study entry), 24 and 48 hours later. Plasma cytokine levels were assayed by flow cytometry.Results: Severe TBI was associated with a 42% mortality rate. TBI patients had a significant increase in the levels of all cytokines measured, except for IL-1 beta, compared to controls. Statistically significant increases in the IL-10, -8 and -6 levels were observed in the non-survivors TBI patients compared to the survivors sub-group measured in the first sample (study entry) and in the subsequent sample (24 hours later). There were no significant differences in IL-1 beta, TNF-alpha and IL-12p70 levels between survivors and non-survivors in any time sampled.Conclusions: The findings indicate that increased IL-10, -8 and -6 levels may constitute an early predictor of unfavourable outcome in severe TBI patients.