Molecular biology of lung cancer.
Molecular biology of lung cancer.
复制标题
DOI：
10.1097/00063198-199807000-00004
复制
发表时间：
1998-07-01
影响因子：
3.3
通讯作者：
Carney, D
中科院分区：
文献类型：
--
作者：
Sozzi, G;Carney, D
肺癌是世界范围内死亡的主要原因，在过去的20年里，总体存活率并没有显著提高。在欧洲每年新确诊的15万多例肺癌患者中，只有不到10%的患者能够治愈并享受长期生存。吸烟是导致肺癌的原因之一，这一点已经得到了确凿的证实。肺癌的早期诊断基于常规的痰细胞学和胸部摄影筛查程序，到目前为止还无法降低肺癌死亡率。我们在这里讨论了新的、更特异的分子标志物的可能性，除了提供对肺癌发生过程的新理解外，还可能成为早期诊断的新工具，从而筛查高危个体、确定预后和确定创新的治疗方法。
Lung cancer is a major cause of mortality worldwide and the overall survival rate has not improved significantly in the past 20 years. Of the more than 150,000 new cases of lung cancer diagnosed in Europe every year, less than 10% of patients can be cured and enjoy long-term survival. The role of tobacco smoking as a cause of lung cancer has been conclusively established. Early diagnosis of lung cancer, based on conventional screening procedures using sputum cytology and chest radiography, has been so far unable to decrease lung cancer mortality. We discuss here the possibility that novel, more specific molecular markers, beside providing new understanding of the process of lung carcinogenesis, may also constitute new tools for early diagnosis allowing for screening of high-risk individuals, determination of prognosis, and identification of innovative treatments.