Circulating Th17, Th22, and Th1 cells are increased in psoriasis.
Circulating Th17, Th22, and Th1 cells are increased in psoriasis.
复制标题
DOI：
10.1038/jid.2009.399
复制
发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
在银屑病皮损中检测到Th17、Th22和Th1细胞，并与银屑病的发病机制有关，但血液中炎症T细胞的数量以及每种细胞类型的相对重要性尚不清楚。采用7色流式细胞术，对21例未经治疗的银屑病患者和17例健康人的循环Th17、Th22和Th1细胞进行了定量分析。与IL-23R或CD161相比，CCR6是IL-17A+细胞的最佳细胞表面标记物。银屑病患者CCR6+、IL-17A+、IL-22+、CCR6+ IL-17A+、CCR6+ IL-22+、CCR6+肿瘤坏死因子-α+、IL-17A+ IL-22+ IFN-γ−、IL-17A+ IL-22+ IFN-γ−细胞增多（均P < 0.001），表明循环Th17细胞增多，使用多种标准来定义这些细胞。银屑病患者Th22 （IL-17A−IL-22 + IFN-γ−,P < 0.05）和Th1 （IL-17A−IFN-γ+, P < 0.05）细胞也增加，但程度较轻。体外抑制NF-κB或STAT3均可阻断Th17和Th1细胞产生细胞因子。在英夫利昔单抗诱导治疗后，对5例银屑病患者的循环Th17和Th1细胞水平进行了连续评估。总之，循环炎性T细胞数量的升高可能导致牛皮癣患者发生皮肤炎症和全身性炎症疾病。
Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals. CCR6 was the best cell surface marker for IL-17A+ cells when compared with IL-23R or CD161. CCR6+, IL-17A+, IL-22+, CCR6+ IL-17A+, CCR6+ IL-22+, CCR6+ tumor necrosis factor-α+, IL-17A + IFN-γ−, IL-17A + IL-22 + IFN-γ−, and IL-17A + IL-22−IFN-γ− cells were increased in psoriatics (all values P < 0.001), indicating elevations in circulating Th17 cells, using multiple criteria to define these cells. Th22 (IL-17A−IL-22 + IFN-γ−, P < 0.05) and Th1 (IL-17A−IFN-γ+, P < 0.05) cells were also increased in psoriatics, but to a lesser extent. Inhibition of either NF-κB or STAT3 in vitro blocked cytokine production by both Th17 and Th1 cells. Circulating levels of Th17 and Th1 cells decreased in a subset of five psoriasis patients serially evaluated following induction therapy with infliximab. In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis.
登录
查看更多内容
DOI：
10.4049/jimmunol.181.7.4733
发表时间：
2008-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kryczek I;Bruce AT;Gudjonsson JE;Johnston A;Aphale A;Vatan L;Szeliga W;Wang Y;Liu Y;Welling TH;Elder JT;Zou W
通讯作者：
Zou W
影响因子：
120.7
作者：
Gelfand, Joel M.;Neimann, Andrea L.;Troxel, Andrea B.
通讯作者：
Troxel, Andrea B.
影响因子：
30.8
作者：
Nair RP;Duffin KC;Helms C;Ding J;Stuart PE;Goldgar D;Gudjonsson JE;Li Y;Tejasvi T;Feng BJ;Ruether A;Schreiber S;Weichenthal M;Gladman D;Rahman P;Schrodi SJ;Prahalad S;Guthery SL;Fischer J;Liao W;Kwok PY;Menter A;Lathrop GM;Wise CA;Begovich AB;Voorhees JJ;Elder JT;Krueger GG;Bowcock AM;Abecasis GR;Collaborative Association Study of Psoriasis
通讯作者：
Collaborative Association Study of Psoriasis
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
人白细胞介素17产生的细胞起源于CD161+ CD4+ T细胞前体。
影响因子：
15.3
作者：
Cosmi, Lorenzo;De Palma, Raffaele;Santarlasci, Veronica;Maggi, Laura;Capone, Manuela;Frosali, Francesca;Rodolico, Gabriella;Querci, Valentina;Abbate, Gianfranco;Angeli, Roberta;Berrino, Liberato;Fambrini, Massimiliano;Caproni, Marzia;Tonelli, Francesco;Lazzeri, Elena;Parronchi, Paola;Liotta, Francesco;Maggi, Enrico;Romagnani, Sergio;Annunziato, Francesco
通讯作者：
Annunziato, Francesco