Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging
Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging
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DOI：
10.1161/01.cir.93.8.1502
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发表时间：
1996-04-15
期刊：
影响因子：
37.8
通讯作者：
Peshock, RM
中科院分区：
文献类型：
--
作者：
Hundley, WG;Lange, RA;Peshock, RM
研究背景：无创性测量心外膜冠状动脉绝对血流和血流储备可用于评价冠状动脉循环障碍患者。相位对比磁共振成像（PC-MRI）已被用于测量冠状动脉血流在动物中，但其准确性在humanisunknow.Methods和结果12名受试者（7名男性：5名女性;年龄，44至67岁）进行了PC-MRI测量的流量在左前降支冠状动脉或其对角分支之一，在休息和腺苷（140 μ g . kg（-1）。min（-1）IV）。此后，立即在静息和静脉注射腺苷后进行心导管插入术期间进行冠状动脉内多普勒速度（IDV）和流量测量。对于12例患者，冠状动脉血流和冠状动脉血流储备的MRI和侵入性测量之间的相关性极佳：冠状动脉血流（MRI）（mL/min）=0.85 X冠状动脉血流（IDV）（mL/min）+17（mL/min），r= 0.89，冠状动脉血流储备（MRI）=0.79 X冠状动脉血流储备（IDV）+0.34，r= 0.89。冠状动脉血流范围（18至161 mL/min），MRI和导管测量之间的一致性限度为-13+/-30 mL/min;冠状动脉储备的范围（0.7至3.7）通过MRI测量，两种技术之间的一致性界限为0.1 ± 0.4。结论电影速度编码的PC-MRI可以无创地测量人类左前降支的绝对冠状动脉血流。PC-MRI可以检测冠状动脉血流的变化，并可以可靠地区分正常和异常冠状动脉血流储备的受试者。
Background The noninvasive measurement of absolute epicardial coronary arterial flow and flow reserve would be useful in the evaluation of patients with coronary circulatory disorders. Phase-contrast magnetic resonance imaging (PC-MRI) has been used to measure coronary arterial flow in animals, but its accuracy in humans is unknown.Methods and Results Twelve subjects (7 men: 5 women; age, 44 to 67 years) underwent PC-MRI measurements of flow in the left anterior descending coronary artery or one of its diagonal branches at rest and after administration of adenosine (140 mu g . kg(-1). min(-1) IV). Immediately thereafter, intracoronary Doppler velocity (IDV) and flow measurements were made during cardiac catheterization at rest and after intravenous administration of adenosine. For the 12 patients, the correlation between MRI and invasive measurements of coronary arterial flow and coronary arterial flow reserve was excellent: coronary flow(MRI) (mL/min)=0.85 X coronary flow(IDV) (mL/min)+17 (mL/min), r=.89, and coronary flow reserve(MRI)=0.79 X coronary velocity reserve(IDV)+0.34, r=.89. For the range of coronary arterial flows (18 to 161 mL/min) measured by MRI, the limit of agreement between MRI and catheterization measurements of flow was -13+/-30 mL/min; for the range of coronary reserves (0.7 to 3.7) measured by MRI, the limit of agreement between the two techniques was 0.1+/-0.4.Conclusions Cine velocity-encoded PC-MRI can noninvasively measure absolute coronary arterial flow in the left anterior descending artery in humans. PC-MRI can detect pharmacologically induced changes in coronary arterial flow and can reliably distinguish between those subjects with normal and abnormal coronary artery flow reserve.