Catalytic concepts for the enantioselective synthesis of alpha-amino and alpha-hydroxy phosphonates.
Catalytic concepts for the enantioselective synthesis of alpha-amino and alpha-hydroxy phosphonates.
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DOI：
10.1002/(sici)1521-3765(20000317)6:6
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发表时间：
2000-03
期刊：
影响因子：
--
通讯作者：
H. Gröger;B. Hammer
中科院分区：
文献类型：
--
作者：
H. Gröger;B. Hammer
通过催化过程对映选择性合成α -氨基和α -羟基膦酸盐在过去几年中引起了相当大的兴趣，尤其是因为对这些化合物的药物兴趣。这篇文章包含了迄今为止发展的不对称合成方法的汇编。所描述的合成路线是基于不同的催化概念，即氢化，还原，二羟基化，氨基羟基化和氢膦化。
The enantioselective synthesis of alpha-amino- and alpha-hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed to date. The described synthetic routes are based on different catalytic concepts, namely, hydrogenation, reductions, dihydroxylation, aminohydroxylation, and hydrophosphonylation.