Hippocampal atrophy in recurrent major depression
Hippocampal atrophy in recurrent major depression
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DOI：
10.1073/pnas.93.9.3908
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发表时间：
1996-04-30
影响因子：
11.1
通讯作者：
Vannier, MW
中科院分区：
文献类型：
--
作者：
Sheline, YI;Wang, PW;Vannier, MW
使用体积磁共振成像将有重度抑郁发作史但目前处于缓解期且无已知医学合并症的受试者的海马体积与匹配的正常对照进行比较。重度抑郁史受试者的左右海马体积明显较小，但总脑容量无差异。海马体积减小程度与重性抑郁总持续时间相关。此外，海马体内存在较大的（直径大于或等于4.5 mm）海马低信号灶（LSF），其数量也与抑郁总天数相关。这些结果表明抑郁症与海马萎缩有关，可能是由于糖皮质激素神经毒性介导的进行性过程。
Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. Subjects with a history of major depression had significantly smaller left and right hippocampal volumes with no differences in total cerebral volumes. The degree of hippocampal volume reduction correlated with total duration of major depression. In addition, large (diameter greater than or equal to 4.5 mm)-hippocampal low signal foci (LSF) were found within the hippocampus, and their number also correlated with the total number of days depressed. These results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.