Prevention of surgical adhesions with barriers of carboxymethylcellulose and poly(ethylene glycol) hydrogels synthesized by irradiation
Prevention of surgical adhesions with barriers of carboxymethylcellulose and poly(ethylene glycol) hydrogels synthesized by irradiation
复制标题
DOI：
10.1002/app.21558
复制
发表时间：
2005-05-15
影响因子：
3
通讯作者：
Son, TI
中科院分区：
文献类型：
--
作者：
Lee, JH;Nho, YC;Son, TI
制备了基于羧甲基纤维素（CMC）和聚乙二醇（PEG）的生物相容性和可生物降解的水凝胶，作为预防手术粘连的物理屏障。这些互聚物水凝胶的γ-辐照交联技术合成。用骨钻研磨盲肠浆膜和邻近腹壁的切片（1.5 cm X 1.5 cm），直至浆膜表面破裂并出血但未穿孔，然后将盲肠浆膜缝合到距受伤部位5 mm处的腹壁上。用CMC/PEG水凝胶或来自CMC/PEG水凝胶的溶液覆盖裸露的盲肠。未覆盖对照大鼠浆膜。两周后，处死大鼠，并以0-5分制对粘连进行评分。没有治疗显示出比CMC/PEG水凝胶或来自CMC/PEG水凝胶的溶液显著更高的粘连发生率。该研究表明，CMC/ PEG水凝胶可以防止大鼠模型中的腹腔内粘连。(c)2005 Wiley Periodicals，Inc.
Biocompatible and biodegradable hydrogels based on carboxymethylcellulose (CMC) and poly(ethylene glycol) (PEG) were prepared as physical barriers for preventing surgical adhesions. These interpolymeric hydrogels were synthesized by a gamma-irradiation crosslinking technique. Sections (1.5 cm X 1.5 cm) of the cecal serosa and an adjacent abdominal wall were abraded with a bone burr until the serosal surface was disrupted and hemorrhagic but not perforated, and the serosa of the cecum was sutured to the abdominal wall 5 mm away from the injured site. The denuded cecum was covered with either CMC/PEG hydrogels or a solution from a CMC/PEG hydrogel. A control rat serosa was not covered. Two weeks later, the rats were killed, and the adhesions were scored on a 0-5 scale. No treatment showed a significantly higher incidence of adhesions than the CMC/PEG hydrogels or solutions from the CMC/PEG hydrogels. This study demonstrated that CMC/ PEG hydrogels could prevent intra-abdominal adhesion in a rat model. (c) 2005 Wiley Periodicals, Inc.