Evaluation of cardiac repolarization indices in well-controlled partial epilepsy: 12-Lead ECG findings
Evaluation of cardiac repolarization indices in well-controlled partial epilepsy: 12-Lead ECG findings
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DOI：
10.1016/j.eplepsyres.2010.04.008
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Gok, Hasan
中科院分区：
文献类型：
--
作者：
Dogan, Ebru Apaydin;Dogan, Umuttan;Gok, Hasan
目的：目的：探讨控制良好的部分性癫痫患者的心脏复极指标，并与QT间期进行比较。方法：选择控制良好的部分性癫痫患者76例，健康对照者66例。12-从所有参与者处获得导联ECG。计算校正的QT（QTc）间期，包括最大QTc（QTmaxc）、最小QTc（QTminc）和QTc离散度（QTcd）。与对照组相比，癫痫组的QTmaxc和QTcd间期显著延长（439 +/-27 ms vs. 422 +/-25 ms，p <0.001和55 +/-18 ms vs. 41 +/-18 ms，p <0.001）。癫痫组中QTcd间期病理性延长（> 50 ms）的患者比例显著较高（76例中有25例vs. 66例中有7例，p = 0.002）。校正性别、体重指数和癫痫持续时间后，QTmaxc与年龄显著相关（β = 0.29，p = 0.012）。癫痫持续时间与任何QT间期之间均未观察到相关性。根据癫痫发作的病因（症状性/隐源性），单药或多药治疗和治疗方案（卡马西平/非卡马西平）的QT间期亚组之间没有显着差异。结论：结果突出了心脏评估的重要性，即使在癫痫控制良好的患者。12-导联ECG记录可能有助于发现严重心血管事件。(C)2010 Elsevier B.V.保留所有权利。
Purpose: To evaluate the cardiac repolarization indices in terms of QT intervals in patients with well-controlled partial epilepsy.Methods: Seventy-six adult patients with well-controlled partial epilepsy and 66 healthy controls were enrolled into the study. 12-Lead ECGs were obtained from all participants. Corrected QT (QTc) intervals including maximum QTc (QTmaxc), minimum QTc (QTminc) and QTc dispersion (QTcd) were calculated.Results: QTmaxc and QTcd intervals were significantly longer in the epilepsy group when compared to control group (439 +/- 27 ms vs. 422 +/- 25 ms, p < 0.001 and 55 +/- 18 ms vs. 41 +/- 18 ms, p < 0.001). The proportion of patients with pathologically prolonged QTcd intervals (>50 ms) was significantly higher in the epilepsy group (25 of 76 vs. 7 of 66, p = 0.002). QTmaxc was significantly correlated with age (beta = 0.29, p = 0.012) after adjusting for gender, body mass index and duration of epilepsy. No correlation was observed between the duration of epilepsy and any of the QT intervals. There were no significant differences between the subgroups regarding QT intervals according to the etiology of the seizures (symptomatic/cryptogenic), being on mono- or polytherapy and treatment regimens (carbamazepine/non-carbamazepine).Conclusion: The results highlight the importance of cardiac evaluation even in patients with well-controlled epilepsy. 12-lead ECG recordings might help to uncover serious cardiovascular events. (C) 2010 Elsevier B.V. All rights reserved.