EM2D9, a monoclonal antibody against Integrin a5b1, has potent antitumor activity on endometrial cancer in vitro and in vivo.
EM2D9, a monoclonal antibody against Integrin a5b1, has potent antitumor activity on endometrial cancer in vitro and in vivo.
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EM2D9 是一种针对 Integrin a5b1 的单克隆抗体，在体外和体内对子宫内膜癌具有有效的抗肿瘤活性。
DOI：
10.1016/j.canlet.2020.02.019
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发表时间：
2020-03
期刊：
影响因子：
9.7
通讯作者：
Guoqing Wang
中科院分区：
文献类型：
--
作者：
Yinyan Xu;Yi Li;Jiahui Pan;Xing Kang;Xu Zhang;Xinyi Feng;Shucheng Li;Chengxi Li;Jinku Zhang;Chong Li;Guoqing Wang
子宫内膜癌是一种原发于子宫内膜的上皮性恶性肿瘤，是女性生殖系统最常见的三大恶性肿瘤之一。虽然子宫内膜癌的发病率最近一直在上升，但其病因仍不清楚。本研究发现EM2D9是一种特异性识别子宫内膜癌细胞的单克隆抗体，并进一步确定其靶蛋白为α5β 1。体外和体内实验表明EM2D9抑制子宫内膜癌细胞的迁移。实时定量PCR结果显示，EM 2D 9处理后子宫内膜癌细胞中CD 151 mRNA的表达明显下降。我们还发现EM2D9影响FAK信号通路。总的来说，这些结果揭示了子宫内膜癌发展的新机制。
Endometrial cancer, a type of primary epithelial malignant tumor in the endometrium, is one of the three most common malignant tumors of the female reproductive system. While the incidence of endometrial cancer has been recently rising, its etiology remains unclear. In this study we found that EM2D9, an independently developed monoclonal antibody, specifically recognized endometrial cancer cells; we further determined that EM2D9 target protein was α5β1.In vitroandin vivoexperiments showed that EM2D9 inhibited the migration of endometrial cancer cells. Real-time quantitative PCR results showed that the expression of CD151 mRNA in endometrial carcinoma cells significantly decreased after EM2D9 treatment. We also found that EM2D9 affected the FAK signaling pathway. Collectively, these results shed light on a new mechanism for the development of endometrial carcinoma.
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DOI：
--
发表时间：
2002-08
期刊：
The Journal of experimental biology
影响因子：
--
作者：
M. Flück;A. Ziemiecki;R. Billeter;M. Müntener
通讯作者：
M. Flück;A. Ziemiecki;R. Billeter;M. Müntener
DOI：
--
发表时间：
2000
期刊：
--
影响因子：
--
作者：
D. Livant;R. K. Brabec;K. Pienta;David L. Allen;K. Kurachi;S. Markwart;Ameet Upadhyaya
通讯作者：
D. Livant;R. K. Brabec;K. Pienta;David L. Allen;K. Kurachi;S. Markwart;Ameet Upadhyaya
DOI：
10.1083/jcb.201502040
发表时间：
2015-09-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Paul NR;Allen JL;Chapman A;Morlan-Mairal M;Zindy E;Jacquemet G;Fernandez del Ama L;Ferizovic N;Green DM;Howe JD;Ehler E;Hurlstone A;Caswell PT
通讯作者：
Caswell PT
影响因子：
4.4
作者：
H. Hasegawa;Tetsuhiko Nomura;Kyoko Kishimoto;K. Yanagisawa;S. Fujita
通讯作者：
H. Hasegawa;Tetsuhiko Nomura;Kyoko Kishimoto;K. Yanagisawa;S. Fujita
影响因子：
64.5
作者：
TAMKUN, JW;DESIMONE, DW;HYNES, RO
通讯作者：
HYNES, RO