Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia
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DOI：
10.1148/radiol.2020200274
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发表时间：
2020-04-01
期刊：
影响因子：
19.7
通讯作者：
Shi, Yuxin
中科院分区：
文献类型：
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作者：
Song, Fengxiang;Shi, Nannan;Shi, Yuxin
背景：2019新型冠状病毒(2019-nCoV)肺炎患者的胸部CT表现未见详细描述。目的：探讨2019-nCoV肺炎患者的临床、实验室及影像表现。材料与方法：对51例经实验室确诊的2019-nCoV感染患者进行薄层CT扫描。结果：51例患者中有50例(98%)有与武汉市中国疾控中心人员有接触史。发热(49/51，96%)和咳嗽(24/51，47%)是最常见的症状。大多数患者白细胞计数正常(37/51，73%)，中性粒细胞计数正常(44/51，86%)，淋巴细胞计数正常(17/51，35%)或降低(33/51，65%)。CT表现为单纯磨玻璃样混浊39例(77%)，伴网状和/或小叶间隔增厚38例(75%)。51名患者中有30名(59%)出现GGO合并实变，而51名患者中有28名(55%)出现单纯实变。其中双侧肺受累44例(86%)，肺后部受累41例(80%)，周围肺受累44例(86%)。从发病到CT扫描的5天或更长时间的患者有更多的实变型肺部病变，而4天或更少的患者(712个病变中的431个与612个病变中的129个；P，.001)。年龄大于50岁的患者比年龄小于或等于50岁的患者有更多的实变型肺部病变(470例患者中212例，854例患者中198例；P<0.001)。13例患者随诊CT有7例(54%)改善，4例(31%)进展。结论：发热、咳嗽、外周及后部或肺部有明显磨玻璃样阴影病变、白细胞正常或减少、有传染病暴露史的患者，高度怀疑2019年新型冠状病毒肺炎。(C)RSNA，2020年
Background: The chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously beendescribed in detail.Purpose: To investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and Methods: Fifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated.Results: Fifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocytecount. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients,and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement,while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer ( 431 of 712 lesions vs 129 of 612 lesions; P,.001). Patients older than 50 years had more consolidated lung lesions than did those aged 50 years or younger (212 of 470 vs 198 of 854; P,.001). Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients.Conclusion: Patients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posteri or lungson CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia. (C) RSNA, 2020