Optogenetic stimulation of DAergic VTA neurons increases aggression.
Optogenetic stimulation of DAergic VTA neurons increases aggression.
复制标题
DAergic VTA 神经元的光遗传学刺激会增加攻击性。
DOI：
10.1038/mp.2014.45
复制
发表时间：
2014
影响因子：
11
通讯作者：
Ansorge,MS
中科院分区：
文献类型：
--
作者：
Yu,Q;Teixeira,CM;Mahadevia,D;Huang,Y-Y;Balsam,D;Mann,JJ;Gingrich,JA;Ansorge,MS
DATIRESCRE：AI32双突变小鼠在DAR能神经元表达ChR2-EYFP。单一突变小鼠不表达ChR2-EYFP，并作为对照。将光缆植入小鼠体内，其顶端正好位于VTA的背侧。对混合对DATIRESCRE：AI32双转基因小鼠和单突变对照小鼠的攻击行为进行了评估。两只老鼠中只有一只受到了刺激。当DATIRESCRE：AI32双突变小鼠受到刺激时，攻击性行为成对增加，而单突变对照小鼠则受到刺激。关于这个话题的更多信息，请参考Yu等人的文章。在688-698页。
DATIRESCre: ai32 double-mutant mice express ChR2-eYFP in DAergic neurons. Single-mutant mice do not express ChR2-eYFP and served as controls. Fiberoptic cables were implanted into mice with their tips just dorsal to the VTA. Aggressive behavior was assessed in mixed pairs of DATIRESCre: ai32 double-transgenic mice and single-mutant controls. Only one mouse in a pair was stimulated. Aggressive behavior was increased in pairs when DATIRESCre: ai32 double-mutant mice were stimulated when compared to pairs where the single-mutant controls were stimulated. For more information on this topic, please refer to the article by Yu et al. on pages 688-698.