Reduction in mouse allergen exposure is associated with greater lung function growth
Reduction in mouse allergen exposure is associated with greater lung function growth
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DOI：
10.1016/j.jaci.2019.08.043
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发表时间：
2020-02-01
影响因子：
14.2
通讯作者：
Matsui, Elizabeth C.
中科院分区：
文献类型：
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作者：
Grant, Torie;Phipatanakul, Wanda;Matsui, Elizabeth C.
背景：目前的儿童哮喘治疗对肺功能轨迹的影响很小。目的：我们试图确定小鼠过敏原暴露减少是否与小鼠致敏/暴露的哮喘儿童肺功能生长有关。方法：350名小鼠致敏/暴露的哮喘儿童（5-17岁）参加了一项为期1年的害虫综合管理加教育与单独教育的随机试验。在基线、6个月和12个月时进行支气管扩张剂前/扩张剂后肺活量测定，每3个月测量一次卧室地板小鼠过敏原水平。小鼠过敏原减少的定义是小鼠过敏原水平从基线下降75%或更多。治疗组合并分析，因为两组之间的结果没有差异。对肺功能随时间的变化进行建模，调整年龄、性别、种族、特应性、组和支气管扩张剂可逆性，并包括相互作用项（过敏原减少*时间）。结果：研究人群以黑人（79.4%）和低收入者（66.3%）为主。
Background: Current childhood asthma therapies have little effect on lung function trajectory. Objective: We sought to determine whether mouse allergen exposure reduction is associated with lung function growth in mouse-sensitized/exposed asthmatic children.Methods: Three hundred fifty mouse-sensitized/exposed asthmatic children (5-17 years old) were enrolled in a 1-year randomized trial of integrated pest management plus education versus education alone. Prebronchodilator/postbronchodilator spirometry was performed at baseline and 6 and 12 months, and bedroom floor mouse allergen levels were measured every 3 months. Mouse allergen reduction was defined as a 75% or greater decrease in mouse allergen levels from baseline. Treatment groups were combined for analyses because there were no differences in outcomes between groups. Changes in lung function over time were modeled, adjusting for age, sex, race, atopy, group, and bronchodilator reversibility and including an interaction term (allergen reduction*time).Results: The study population was predominantly black (79.4%) and low income (66.3% [