New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L.
New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L.
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DOI：
10.1248/cpb.56.730
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发表时间：
2008-05-01
影响因子：
1.7
通讯作者：
Takeya, Koichi
中科院分区：
文献类型：
--
作者：
Lee, Ji-Ean;Hitotsuyanagi, Yukio;Takeya, Koichi
从茜草科 (Rubia cordifolia L.) 的根中分离出两种新的双环六肽 RAAXIII 和 RA-XXIV。通过分析 2D NMR 谱、化学方法和 X 射线晶体学，确定了它们的结构。 RA-XXIII和RA-XXIV针对P-388白血病细胞的IC 50 值分别为0.16和0.48μg/ml。
Two new bicyclic hexapeptides, RAAXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 mu g/ml, respectively.