A putative cyclic nucleotide-gated channel is required for sensory development and function in C-elegans
A putative cyclic nucleotide-gated channel is required for sensory development and function in C-elegans
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DOI：
10.1016/s0896-6273(00)80201-9
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发表时间：
1996-10-01
期刊：
影响因子：
16.2
通讯作者：
Bargmann, CI
中科院分区：
文献类型：
--
作者：
Coburn, CM;Bargmann, CI
在脊椎动物的视觉和嗅觉系统中，一个环核苷酸门控通道将感觉神经元的受体激活与电活动结合起来。秀丽隐杆线虫Tax-2基因是一些嗅觉农场、盐类化学传感和温度传感所必需的。我们在这里表明，TAX-2编码在嗅觉、味觉和温度感觉神经元中表达的环核苷酸门控通道的一个预测亚单位，这意味着该通道在多种感觉模式中都有表达。在TAX-2突变体中，一些感觉神经元显示出轴突生长缺陷。因此，除了在感觉中的作用外，该通道在感觉神经元发育中也具有意想不到的作用。与这一提出的双重功能一致，TAX-2：：GFP融合蛋白在感觉纤毛和感觉轴突中都存在。
In vertebrate visual and olfactory systems, a cyclic nucleotide-gated channel couples receptor activation to electrical activity of the sensory neurons. The Caenorhabditis elegans tax-2 gene is required for some farms of olfaction, for chemosensation of salts, and for thermosensation. We show here that tax-2 encodes a predicted subunit of a cyclic nucleotide-gated channel that is expressed in olfactory, gustatory, and thermosensory neurons, implicating this channel in multiple sensory modalities. Some sensory neurons display axon outgrowth defects in tax-2 mutants. Thus, the channel has an unexpected role in sensory neuron development in addition to its role in sensation. Consistent with this proposed dual function, a Tax-2::GFP fusion protein is present both in sensory cilia and in sensory axons.