Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.
Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.
复制标题
长循环的，可降解的HPMA共聚物 - 道霉素结合物的合成以及分子量依赖性抗肿瘤功效的评估。
DOI：
10.1002/mabi.201200353
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发表时间：
2013-02
影响因子：
4.6
通讯作者：
Kopeček J
中科院分区：
文献类型：
--
作者：
Pan H;Sima M;Yang J;Kopeček J
Backbone degradable, linear, multiblock N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer–doxorubicin (DOX) conjugates are synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization followed by chain extension via thiol-ene click reaction. The examination of molecular-weight-dependent antitumor activity toward human ovarian A2780/AD carcinoma in nude mice reveals enhanced activity of multiblock, second-generation, higher molecular weight conjugates when compared with traditional HPMA copolymer–DOX conjugates. The examination of body weight changes during treatment indicates the absence of non-specific adverse effects.
