Possible Mechanisms of Trichosanthin-Induced Apoptosis of Tumor Cells
Possible Mechanisms of Trichosanthin-Induced Apoptosis of Tumor Cells
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DOI：
10.1002/ar.21142
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Li, Ji-Cheng
中科院分区：
文献类型：
--
作者：
Li, Meng;Li, Xiang;Li, Ji-Cheng
天花粉蛋白（Trichosanthin，TCS）是从中药天花粉（Trichosanthes kit-down Maximowicz）的块根中分离得到的一种I型核糖体失活蛋白。由于TCS对滋养层细胞的高毒性，TCS在中国被用作堕胎药已有1,500年的历史。在过去的20年里，TCS由于其潜在的抗肿瘤活性而成为许多研究的主题。许多报道显示TCS在体外和体内对多种肿瘤细胞系具有细胞毒性。单克隆抗体偶联TCS可增强其抗肿瘤作用，因此TCS被认为是一种潜在的肿瘤治疗生物制剂。TCS能够抑制蛋白质合成，从而诱导坏死。最近的研究表明，TCS确实在几种肿瘤细胞系中诱导凋亡。虽然TCS诱导肿瘤细胞系的凋亡现在是众所周知的，但其潜在的机制仍有待阐明。本综述的目的是根据已发表的文献和我们自己的研究Anat Rec，293.986-992，2010的结果，研究TCS的作用及其可能的作用机制。(C)2010 Wiley-Liss，Inc.
Trichosanthin (TCS) is a type I ribosome-inactivating protein that is isolated from the root tubers of the Chinese medicinal herb Trichosanthes kit-down Maximowicz. TCS has been used as an abortifacient for 1,500 years in China because of its high toxicity on trophoblasts Over the past 20 years, TCS has been the subject of much research because of its potential antitumor activities Many reports have revealed that TCS is cytotoxic in a variety of tumor cell lines in vitro and in vivo. Monoclonal antibody-conjugated TCS could enhance its antitumor efficacy; thus, TCS is considered to be a potential biological agent for cancer treatment. TCS is able to inhibit protein synthesis and consequently induce necrosis Recent studies have demonstrated that TCS does Indeed induce apoptosis in several tumor cell lines. Although TCS-induced apoptosis of tumor cell lines is now well known, the underlying mechanisms remain to be elucidated. The purpose of this review was to investigate the effects of TCS and its possible mechanisms of action, based on published literature and the results of our own studies Anat Rec, 293.986-992, 2010. (C) 2010 Wiley-Liss, Inc.