Regulation of hippocampal neurogenesis in adulthood
Regulation of hippocampal neurogenesis in adulthood
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DOI：
10.1016/s0006-3223(00)01021-0
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发表时间：
2000-10-15
影响因子：
10.6
通讯作者：
Hastings, N
中科院分区：
文献类型：
--
作者：
Gould, E;Tanapat, P;Hastings, N
在包括人类在内的多种哺乳动物物种的成年期，齿状回会产生大量新的颗粒神经元。大量研究表明，新海马神经元的产生和存活可以通过激素和经验来增强或减弱。卵圆和肾上腺的类固醇激素已被证明可以通过影响颗粒细胞前体的增殖来调节未成熟神经元的产生。厌恶的经历已被证明会减少未成熟颗粒细胞的产生，而丰富的经历（包括学习）已被证明可以提高新海马细胞的存活率。这些研究表明，成人产生的神经元代表了一种独特的结构可塑性形式，可以受到环境的调节，并且进一步表明新的神经元在海马功能中发挥着重要作用。生物精神病学 2000；48：715-720 (C) 2000 生物精神病学协会。
A substantial number of new granule neurons are produced in the dentate gyrus in adulthood in a variety of mammalian species, including humans. Numerous studies have demonstrated that the production and survival of new hippocampal neurons can be enhanced or diminished by hormones and experience. Steroid hormones of the oval-ies and adrenal glands have been shown to modulate the production of immature neurons by affecting the proliferation of granule cell precursors. Aversive experiences have been demonstrated to decrease the production of immature granule cells, whereas enriching experiences, including learning, have been shown to enhance the survival of new hippocampal cells. These studies indicate that adult-generated neurons represent a unique form of structural plasticity that can be regulated by the environment, and furthermore suggest that new neurons play an important role in hippocampal function. Biol Psychiatry 2000;48:715-720 (C) 2000 Society of Biological Psychiatry.