Quantitative analysis of vascularization in the finger joints in patients with rheumatoid arthritis using three-dimensional volumetric ultrasonography with power Doppler
Quantitative analysis of vascularization in the finger joints in patients with rheumatoid arthritis using three-dimensional volumetric ultrasonography with power Doppler
复制标题
能量多普勒三维体积超声对类风湿性关节炎患者手指关节血管化的定量分析
DOI：
10.1007/s10067-011-1811-5
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发表时间：
2012
期刊：
影响因子：
3.4
通讯作者：
Masao Sato,Ayako Sekine,Daisuke Fukuoka,Mitsuru Seishima,Katsuji Shimizu,Toshio Matsuoka
中科院分区：
文献类型：
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作者：
Tsuneo Watanabe,Masao Takemura;Masao Sato,Ayako Sekine,Daisuke Fukuoka,Mitsuru Seishima,Katsuji Shimizu,Toshio Matsuoka
本研究旨在比较三维（3D）和二维（2D）能量多普勒超声（PDUS）的观察者内和观察者间可靠性，并评估3D PDUS与类风湿关节炎（RA）患者临床参数之间的关系。对33例患者的双侧第二、第三掌指关节和第二、第三近端指间关节进行二维和三维PDUS检查。以标准方式对每个关节进行单独的2D PDUS主观评分（范围，0-3）。2D PDUS指数是评估的所有8个关节的评分之和。通过计算机体素计数对3D PDUS体素信号进行定量分析。两种检查的观察者内可靠性均较高（2D PDUS：ICC = 0.957，95%置信区间= 0.818-0.999; 3D PDUS：ICC = 0.998，95%置信区间= 0.998-1.000）。观察者间可靠性也很高（2D PDUS：ICC = 0.993，95%置信区间= 0.806-0.988; 3D PDUS：ICC = 0.999，95%置信区间= 0.999-1.000）。2D PDUS指数与3D PDUS体素计数之间存在显著相关性（r= 0.795;p< 0.001）。3DPDUS体素计数与28个关节疾病活动性评分（DAS 28）-血沉（r= 0.448，p < 0.01）和DAS 28-C反应蛋白（r= 0.383，p < 0.05）呈显著相关。我们的研究表明，三维PDUS的测量可能是一个有价值的工具，用于预测疾病的活动。
This study aimed to compare the intraobserver and interobserver reliability of three-dimensional (3D) and two-dimensional (2D) power Doppler ultrasonography (PDUS) and to assess the relationship between 3D PDUS and clinical parameters in patients with rheumatoid arthritis (RA). Bilateral second/third metacarpophalangeal joints and second/third proximal interphalangeal joints in 33 patients were examined by both 2D and 3D PDUS. Each joint was given a separate 2D PDUS subjective score (range, 0–3) in a standard manner. The 2D PDUS index is the sum of the scores of all eight joints assessed. 3D PDUS voxel signals were quantitatively analyzed by using computerized voxel counts. Intraobserver reliability was high for both examinations (2D PDUS: ICC = 0.957, 95% confidence interval = 0.818–0.999; 3D PDUS: ICC = 0.998, 95% confidence interval = 0.998–1.000). Interobserver reliability was also high (2D PDUS: ICC = 0.993, 95% confidence interval = 0.806–0.988; 3D PDUS: ICC = 0.999, 95% confidence interval = 0.999–1.000). A significant correlation was found between the 2D PDUS index and 3D PDUS voxel count (r= 0.795;p< 0.001). The 3D PDUS voxel count showed significant correlation with 28 joints Disease Activity Score (DAS28)-erythrocyte sedimentation rate (r= 0.448,p< 0.01) and DAS28-C-reactive protein (r= 0.383,p< 0.05). Our study indicates that the measurement of 3D PDUS may be a valuable tool for predicting disease activity.