Airway Reactivity in Children Before and After Stem Cell Transplantation
Airway Reactivity in Children Before and After Stem Cell Transplantation
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DOI：
10.1002/ppul.20964
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发表时间：
2009-09-01
影响因子：
3.1
通讯作者：
Elhasid, Ronit
中科院分区：
文献类型：
--
作者：
Bentur, Lea;Lapidot, Moshe;Elhasid, Ronit
干细胞移植(SCT)与肺部并发症有关。我们遇到了几个SCT后的儿童，他们的临床照片提示有呼吸道高反应性(AHR)，并且有证据表明移植前没有报道过可逆性的呼吸道阻塞。我们评估了SCT后乙酰胆碱激发试验(MCT)评估AHR升高的可能性，并评估了AHR与肺部并发症之间的可能相关性。这是一项前瞻性研究，评估了连续转诊到儿科血液肿瘤科的SCT患者。评估内容包括SCT前后肺功能和MCT检查，以及肺部并发症的评估。33例患者中有21例完成SCT前平均PC(20)为14.3+/-4.1 mg/ml，SCT后PC(20)降至11.2+/-5.6 mg/ml(P=0.018)。呼吸道反应性患者的数量(PC(20))
Stem cell transplantation (SCT) is associated with pulmonary complications. We encountered several children post-SCT with a clinical picture suggestive of airway hyper-reactivity (AHR) and evidence of reversible airway obstruction that was not reported pre-transplant. We evaluated the possibility of increased AHR as assessed by methacholine challenge test (MCT) following the course of SCT and assessed a possible correlation between AHR and pulmonary complications. This was a prospective study evaluating consecutive patients referred for SCT to the Department of Pediatric Hemato-Oncology. Evaluation included pulmonary function test and MCT before and after SCT and assessment of pulmonary complications. Twenty-one of 33 patients completed the study The mean PC(20) was 14.3 +/- 4.1 mg/ml prior to SCT; afterward the mean PC20 decreased to 11.2 +/- 5.6 mg/ml (P = 0.018). The number of patients with airway reactivity (PC(20)