Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults
Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults
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DOI：
10.1128/iai.71.7.3682-3689.2003
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发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
Anstey, NM
中科院分区：
文献类型：
--
作者：
Boutlis, CS;Tjitra, E;Anstey, NM
生活在疟疾传播密集地区的个人表现出天然免疫力，使他们在大多数时间内没有发烧和其他症状，尽管经常寄生。尽管这种寄生虫血症耐受性在儿童中似乎比在成人中更有效（如随年龄增长寄生虫血症发热阈值降低所证明的），但成人确实表现出一定程度的耐受性，但其机制尚不清楚。无症状的疟疾暴露儿童的一氧化氮（NO）水平高于严重疾病的儿童，NO已被认为是疟疾耐受性的介体。然而，高度暴露于疟疾的无症状成人产生高水平基础NO的能力是未知的，因为NO和成人疟疾耐受性之间的关系。因此，NO和疟疾寄生虫血症之间的关系，确定在无症状的成年人从巴布亚，印度尼西亚。成年人恶性疟原虫寄生虫血症有显着增加基础系统NO生产相对于寄生虫血症的巴布亚控制，谁反过来又产生更多的NO比健康的控制从一个地区没有疟疾。免疫球蛋白E水平普遍升高疟疾暴露巴布亚科目，表明肠道寄生虫病的患病率可能很高，nomnalarial感染也可能有助于高基础NO的生产。基础外周血单核细胞（PBMC）NO合酶活性升高，巴布亚人，但与全身NO生产相关性差，这表明NO生产在这种情况下不仅来自PBMC，但也从其他组织和细胞来源。NO的产生与巴布亚成年人的疟疾耐受性有关，并可能有助于疟疾耐受性。
Individuals living in regions of intense malaria transmission exhibit natural immunity that allows them to be without fever and other symptoms for most of the time despite frequent parasitization. Although this tolerance of parasitemia appears to be more effective in children than in adults (as evidenced by lower parasitemia fever thresholds with age), adults do exhibit a degree of tolerance but the mechanism(s) underlying this are unclear. Asymptomatic malaria-exposed children have higher levels of nitric oxide (NO) than children with severe disease, and NO has been proposed as a mediator of malarial tolerance. However, the ability of highly malaria-exposed asymptomatic adults to generate high-level basal NO is unknown, as is the relationship between NO and malaria tolerance in adults. The relationship between NO and malaria parasitemia was therefore determined in asymptomatic adults from Papua, Indonesia. Adults with Plasmodium falciparum parasitemia had markedly increased basal systemic NO production relative to aparasitemic Papuan controls, who in turn produced more NO than healthy controls from a region without malaria. Immunoglobulin E levels were universally elevated in malaria-exposed Papuan subjects, suggesting that the prevalence of intestinal parasitosis may be high and that nomnalarial infection may also contribute to high basal NO production. Basal peripheral blood mononuclear cell (PBMC) NO synthase activity was elevated in Papuans but poorly correlated with systemic NO production, suggesting that NO production in this setting arises not only from PBMCs but also from other tissue and cellular sources. NO production was associated with and may contribute to malaria tolerance in Papuan adults.