Endogenous Retroviruses and Placental Evolution, Development, and Diversity.
Endogenous Retroviruses and Placental Evolution, Development, and Diversity.
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胎盘的主要作用包括物理保护、营养和氧气输入、气体和胎儿废物的输出以及内分泌调节。除了对胎儿的身体保护外，胎盘还必须在整个妊娠期间提供免疫保护。这些基本功能是非常保守的;然而，胎盘无疑是最近进化的器官，具有结构和细胞的多样性。在过去的二十年里，这些差异已经通过来自转座因子的基因和基因控制元件（包括内源性逆转录病毒（ERV））来解释。然而，胎盘结构的差异尚未得到解释或表征。这份手稿解决了ERV的分类及其整合到哺乳动物基因组中，并提供了新的方法来解释为什么胎盘结构已经分化。
The main roles of placentas include physical protection, nutrient and oxygen import, export of gasses and fetal waste products, and endocrinological regulation. In addition to physical protection of the fetus, the placentas must provide immune protection throughout gestation. These basic functions are well-conserved; however, placentas are undoubtedly recent evolving organs with structural and cellular diversities. These differences have been explained for the last two decades through co-opting genes and gene control elements derived from transposable elements, including endogenous retroviruses (ERVs). However, the differences in placental structures have not been explained or characterized. This manuscript addresses the sorting of ERVs and their integration into the mammalian genomes and provides new ways to explain why placental structures have diverged.
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影响因子：
5.4
作者：
Baba, Kenji;Nakaya, Yuki;Miyazawa, Takayuki
通讯作者：
Miyazawa, Takayuki
影响因子：
3.3
作者：
Blaise, S;de Parseval, N;Heidmann, T
通讯作者：
Heidmann, T
影响因子：
3.6
作者：
Chang, C;Chen, PT;Chen, H
通讯作者：
Chen, H
DOI：
10.1073/pnas.1714590114
发表时间：
2017-12-19
影响因子：
11.1
作者：
Cornelis, Guillaume;Funk, Mathis;Heidmann, Thierry
通讯作者：
Heidmann, Thierry
影响因子：
3.8
作者：
Enders, AC;Carter, AM
通讯作者：
Carter, AM