CARING FOR THE CRITICALLY ILL PATIENT Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality
CARING FOR THE CRITICALLY ILL PATIENT Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality
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发表时间：
2010
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通讯作者：
J. Kilgannon;A. E. Jones;N. Shapiro;M. Angelos;B. Milcarek;K. Hunter;J. Parrillo;S. Trzeciak
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作者：
J. Kilgannon;A. E. Jones;N. Shapiro;M. Angelos;B. Milcarek;K. Hunter;J. Parrillo;S. Trzeciak
心脏骤停是心血管疾病最常见的致命后果。即使实现了心脏骤停后自主循环(ROSC)的恢复，大约60%的患者也无法存活到出院。高死亡率归因于心脏骤停综合征，该综合征涉及全脑缺血再灌注损伤、心肌顿抑和缺氧性脑损伤。最近成功的用于ROSC术后神经保护的治疗性低温增加了研究可以改善预后的ROSC后因素的势头。在寻找可改变的ROSC后因子的过程中，补充氧气的作用一直存在争议，补充氧气通常在心脏骤停后高浓度给予患者。当氧气被输送到受伤的大脑时，存在着一种悖论。氧气太少可能会加重缺氧性损伤。过多的氧气可能会增加氧自由基的产生，可能引发细胞损伤和
SUDDEN CARDIAC ARREST IS THE most common lethal consequence of cardiovascular disease. Even if return of spontaneous circulation (ROSC) from cardiac arrest is achieved, approximately 60% of patients will not survive to hospital discharge. The high mortality is attributed to the postcardiac arrest syndrome, which involves global ischemiareperfusion injury, myocardial stunning, and anoxic brain injury. The recent success of therapeutic hypothermia for post-ROSC neuroprotection has increased momentum for investigating post-ROSC factors that can improve outcomes. In the search for modifiable postROSC factors, the role of supplemental oxygen, which is often administered in high concentrations to patients after cardiac arrest has come into controversy. There is a paradox with oxygen when delivered to the injured brain. Too little oxygen may potentiate anoxic injury. Too much oxygen may increase oxygen free radical production, possibly triggering cellular injury and