Differences in the susceptibility of various aldose reductases to inhibition. II.
Differences in the susceptibility of various aldose reductases to inhibition. II.
复制标题
各种醛糖还原酶对抑制的敏感性存在差异。
DOI：
10.1007/978-94-009-9609-0_15
复制
发表时间：
1980
影响因子：
4.4
通讯作者：
L. Chylack
中科院分区：
文献类型：
--
作者：
P. Kador;J. Kinoshita;W. Tung;L. Chylack
比较了人透镜醛糖还原酶（HLAR）、人胎盘醛糖还原酶（HPAR）和大鼠透镜醛糖还原酶（RLAR）对10种结构不同的抑制剂抑制的敏感性。这些酶的敏感性显着差异进行了观察，但是，没有趋势可以预测。一般来说，HPAR似乎比HLAR或RLAR对抑制不敏感，HLAR的敏感性与RLAR比HPAR更相似。这些结果表明，评价醛糖还原酶抑制剂的潜在临床应用可能需要使用来自适当靶组织的人醛糖还原酶。
The susceptibility of human lens aldose reductase (HLAR), human placental aldose reductase (HPAR), and rat lens aldose reductase (RLAR) to inhibition by 10 structurally diverse inhibitors is compared. Significant differences in the susceptibility of these enzymes was observed; however, no trends could be predicted. In general, HPAR appeared to be less susceptible to inhibition than either HLAR or RLAR, with the susceptibility of HLAR being more similar to RLAR than to HPAR. These findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldose reductase from the appropriate target tissue.