The Enflurane Sparing Effect of Sufentanil in Dogs
The Enflurane Sparing Effect of Sufentanil in Dogs
复制标题
舒芬太尼对狗的安氟醚保护作用
DOI：
10.1097/00000542-198710000-00013
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发表时间：
1986
期刊：
影响因子：
8.8
通讯作者：
C. Hug
中科院分区：
文献类型：
--
作者：
R. Hall;M. Murphy;C. Hug
芬太尼对狗体内安氟烷 MAC 的降低存在上限。舒芬太尼 (SUF) 是一种更有效的麻醉剂，在降低安氟烷 MAC 方面可能更有效。为了验证这一假设，我们将 25 只杂种狗分为三组进行了研究。第 1 组 (n = 8) 接受 SUF，输注速率从 0.005 μg·kg-1·min-1 逐渐增加到最大 1.215 μg·kg-1·min-1。在每次输注速率期间，在血浆[SUF]中稳定的SUF浓度下测定MAC。第 2 组 (n = 10) 接受 SUF 治疗，剂量率 (0.007 μg·kg-1·min-1) 旨在使 MAC 降低约 35%，并在平均输注时间 7.6 ± 0.43 小时（平均值 ± SEM）内定期进行 MAC 测定。第 3 组 (n = 7) 接受 1.215 μg·kg-1·min-1，并与第 2 组一样进行研究，输注时间为 6.7 ± 0.42 小时。在第 1 组中，最高输注速率（1.215 μg·kg-1·min-1）产生 [SUF] = 48 ng/nil，并使 MAC 降低 71 ± 6%。这与 [SUF] = 0.92 ng/ml 时发生的减少没有统计学差异（57 ± 7%；输注速率 0.015 μg·kg-1·min-1；P = 0.21）。在第 2 组中，稳定 [SUF] 实现的 MAC 降低程度 (0.54 ± 0.08 ng/ml) 随着时间的推移而下降（开始时的 MAC 降低 = 34 ± 2%，输注结束时为 18 ± 4.0%；P = 0.001），表明出现了耐受性。在第 3 组（1.215 μg·kg-1·min-1）中，输注开始时和输注结束时 MAC 降低程度没有统计学上的显着差异。输注 1.215 μg·kg-1·min-1（第 3 组）近 7 小时所实现的最大减少量与通过一系列逐渐增加的输注速率达到 1.215 μg·kg-1·min-1 所实现的最大减少量没有差异（[SUF] = 48 时第 1 组减少 70.5%，而 41 ng/ml 时第 3 组减少 78%）。作者得出的结论是，SUF 在狗体内的安氟醚 MAC 减少量上限约为 70%。这种减少与实现它的剂量率无关。当血浆浓度低于产生 MAC 最大减少的浓度时，急性耐受性是明显的。
There is a ceiling to the reduction of enflurane MAC by fentanyl in the dog. Sufentanil (SUF), a more potent narcotic, may be more efficacious in reducing enflurane MAC. To test this hypothesis, 25 mongrel dogs were studied in three groups. Group 1 (n = 8) received SUF in progressively increasing infusion rates from 0.005 μg · kg-1 · min-1 to a maximum of 1.215 μg · kg-1 · min-1. MAC was determined at stable SUF concentrations in plasma [SUF] during each infusion rate. Group 2 (n = 10) received SUF at a dose rate (0.007 μg · kg-1 · min-1) designed to produce approximately 35% MAC reduction, and MAC determinations were made at regular intervals over a mean infusion time of 7.6 ± 0.43 h (mean ± SEM). Group 3 (n = 7) received 1.215 μg · kg-1 · min-1 and were studied as in group 2 over an infusion time of 6.7 ± 0.42 h. In group 1, the highest infusion rate (1.215 μg · kg-1 · min-1) produced [SUF] = 48 ng/nil and reduced MAC by 71 ± 6%. This was not statistically different from the reduction which occurred at [SUF] = 0.92 ng/ml (57 ± 7%; infusion rate 0.015 μg · kg-1 · min-1; P = 0.21). In group 2, the degree of MAC reduction achieved by stable [SUF] (0.54 ± 0.08 ng/ml) declined over time (MAC reduction at start = 34 ± 2% versus 18 ± 4.0% at the end of the infusion; P = 0.001), suggesting the development of tolerance. In group 3 (1.215 μg · kg-1 · min-1), there was no statistically significant difference demonstrated between the degree of MAC reduction at the beginning versus the end of the infusion. The maximum reduction achieved by an infusion of 1.215 μg · kg-1 · min-1 (group 3) for nearly 7 h did not differ from that achieved with a series of progressively increasing infusion rates up to 1.215 μg · kg-1 · min-1 (group 1—70.5% reduction at [SUF] = 48 versus group 3—78% at 41 ng/ml). The authors conclude that there was a ceiling of approximately 70% reduction of enflurane MAC by SUF in the dog. This reduction was independent of the dose-rate at which it was achieved. At plasma concentrations below those producing a maximum reduction of MAC, acute tolerance was evident.